Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SPRY3Sprouty RTK signaling antagonist 3. (287 aa)    
Predicted Functional Partners:
cblb
Cbl proto-oncogene B, E3 ubiquitin protein ligase.
    
 0.777
LOC101070370
Uncharacterized protein.
    
 0.777
cbl
Cbl proto-oncogene, E3 ubiquitin protein ligase.
    
 0.777
hddc2
HD domain containing 2.
      
 0.707
tmlhe
Trimethyllysine hydroxylase, epsilon.
      
 0.699
slc25a43
Solute carrier family 25 member 43; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.694
LOC101066220
Coiled-coil-helix-coiled-coil-helix domain containing 4a.
      
 0.631
vamp7
Synaptobrevin-like 1; Belongs to the synaptobrevin family.
      
 0.627
ptpn6
Protein tyrosine phosphatase non-receptor type 6.
    
 0.627
LOC101076633
Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.
    
 0.627
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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