Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC101074306Ring finger protein 126. (294 aa)    
Predicted Functional Partners:
get4
Golgi to ER traffic protein 4 homolog; As part of a cytosolic protein quality control complex, the bag6/bat3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The bag6/bat3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Similarly, the bag6/bat3 complex also functions as a sorting platform [...]
   
 
 0.908
bag6
BCL2 associated athanogene 6.
   
 
 0.898
get3
ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]
    
 
 0.853
LOC101062737
Ubiquitin-like domain-containing protein.
    
 0.652
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
   
 0.648
faf2
Fas associated factor family member 2.
    
 
 0.599
otub1
Ubiquitin thioesterase.
    
 0.586
LOC101069170
Ubiquitin-conjugating enzyme E2D 4 (putative); Belongs to the ubiquitin-conjugating enzyme family.
   
 0.578
LOC101070684
Ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.
   
 0.578
LOC101078887
Ubiquitin-conjugating enzyme E2D 3; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.578
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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