klf4 protein (Takifugu rubripes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

klf4

Kruppel-like factor 4. (445 aa)

Predicted Functional Partners:

cebpd

0.580

lmo2

0.515

LOC101074260

0.439

LOC101080066

0.421

Sox2

0.419

myc

0.416

LOC101073193

0.414

ldb1

0.414

rps27a

0.409

gata3

0.408

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101073193	gata3	ENSTRUP00000060291	ENSTRUP00000026306	LIM domain binding 1a.	GATA binding protein 3.	0.550
LOC101073193	klf4	ENSTRUP00000060291	ENSTRUP00000024154	LIM domain binding 1a.	Kruppel-like factor 4.	0.414
LOC101073193	lmo2	ENSTRUP00000060291	ENSTRUP00000050214	LIM domain binding 1a.	LIM domain only 2 (rhombotin-like 1).	0.934
LOC101074260	Sox2	ENSTRUP00000027065	ENSTRUP00000011608	POU domain protein.	SRY-box transcription factor 2.	0.843
LOC101074260	klf4	ENSTRUP00000027065	ENSTRUP00000024154	POU domain protein.	Kruppel-like factor 4.	0.439
LOC101074260	myc	ENSTRUP00000027065	ENSTRUP00000022101	POU domain protein.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.556
LOC101080066	klf4	ENSTRUP00000031457	ENSTRUP00000024154	Androgen receptor.	Kruppel-like factor 4.	0.421
Sox2	LOC101074260	ENSTRUP00000011608	ENSTRUP00000027065	SRY-box transcription factor 2.	POU domain protein.	0.843
Sox2	klf4	ENSTRUP00000011608	ENSTRUP00000024154	SRY-box transcription factor 2.	Kruppel-like factor 4.	0.419
cebpd	klf4	ENSTRUP00000054930	ENSTRUP00000024154	CCAAT/enhancer-binding protein.	Kruppel-like factor 4.	0.580
gata3	LOC101073193	ENSTRUP00000026306	ENSTRUP00000060291	GATA binding protein 3.	LIM domain binding 1a.	0.550
gata3	klf4	ENSTRUP00000026306	ENSTRUP00000024154	GATA binding protein 3.	Kruppel-like factor 4.	0.408
gata3	ldb1	ENSTRUP00000026306	ENSTRUP00000071494	GATA binding protein 3.	LIM domain binding 1a.	0.550
gata3	lmo2	ENSTRUP00000026306	ENSTRUP00000050214	GATA binding protein 3.	LIM domain only 2 (rhombotin-like 1).	0.669
klf4	LOC101073193	ENSTRUP00000024154	ENSTRUP00000060291	Kruppel-like factor 4.	LIM domain binding 1a.	0.414
klf4	LOC101074260	ENSTRUP00000024154	ENSTRUP00000027065	Kruppel-like factor 4.	POU domain protein.	0.439
klf4	LOC101080066	ENSTRUP00000024154	ENSTRUP00000031457	Kruppel-like factor 4.	Androgen receptor.	0.421
klf4	Sox2	ENSTRUP00000024154	ENSTRUP00000011608	Kruppel-like factor 4.	SRY-box transcription factor 2.	0.419
klf4	cebpd	ENSTRUP00000024154	ENSTRUP00000054930	Kruppel-like factor 4.	CCAAT/enhancer-binding protein.	0.580
klf4	gata3	ENSTRUP00000024154	ENSTRUP00000026306	Kruppel-like factor 4.	GATA binding protein 3.	0.408