s1pr1 protein (Takifugu rubripes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

s1pr1

Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (373 aa)

Predicted Functional Partners:

LOC101080225

0.926

cdkal1

0.563

dph5

0.544

lrrc39

0.530

dbt

0.529

rtca

0.527

gna12

0.512

slc30a7

0.491

lman2

0.465

vcam1

0.462

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101080225	s1pr1	ENSTRUP00000030129	ENSTRUP00000024703	Sphingosine-1-phosphate receptor 4; Belongs to the G-protein coupled receptor 1 family.	Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.926
cdkal1	lman2	ENSTRUP00000084779	ENSTRUP00000002773	CDK5 regulatory subunit associated protein 1-like 1.	Lectin, mannose-binding 2.	0.475
cdkal1	s1pr1	ENSTRUP00000084779	ENSTRUP00000024703	CDK5 regulatory subunit associated protein 1-like 1.	Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.563
dbt	dph5	ENSTRUP00000051176	ENSTRUP00000059624	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Diphthamide biosynthesis 5.	0.570
dbt	lrrc39	ENSTRUP00000051176	ENSTRUP00000021291	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Leucine rich repeat containing 39.	0.660
dbt	rtca	ENSTRUP00000051176	ENSTRUP00000005628	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	RNA 3'-terminal phosphate cyclase.	0.697
dbt	s1pr1	ENSTRUP00000051176	ENSTRUP00000024703	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.529
dbt	slc30a7	ENSTRUP00000051176	ENSTRUP00000063912	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Solute carrier family 30 member 7.	0.513
dph5	dbt	ENSTRUP00000059624	ENSTRUP00000051176	Diphthamide biosynthesis 5.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.570
dph5	lrrc39	ENSTRUP00000059624	ENSTRUP00000021291	Diphthamide biosynthesis 5.	Leucine rich repeat containing 39.	0.600
dph5	rtca	ENSTRUP00000059624	ENSTRUP00000005628	Diphthamide biosynthesis 5.	RNA 3'-terminal phosphate cyclase.	0.832
dph5	s1pr1	ENSTRUP00000059624	ENSTRUP00000024703	Diphthamide biosynthesis 5.	Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.544
dph5	slc30a7	ENSTRUP00000059624	ENSTRUP00000063912	Diphthamide biosynthesis 5.	Solute carrier family 30 member 7.	0.637
dph5	vcam1	ENSTRUP00000059624	ENSTRUP00000023944	Diphthamide biosynthesis 5.	Ig-like domain-containing protein.	0.457
gna12	s1pr1	ENSTRUP00000029080	ENSTRUP00000024703	G protein subunit alpha 12.	Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.512
lman2	cdkal1	ENSTRUP00000002773	ENSTRUP00000084779	Lectin, mannose-binding 2.	CDK5 regulatory subunit associated protein 1-like 1.	0.475
lman2	s1pr1	ENSTRUP00000002773	ENSTRUP00000024703	Lectin, mannose-binding 2.	Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.465
lrrc39	dbt	ENSTRUP00000021291	ENSTRUP00000051176	Leucine rich repeat containing 39.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.660
lrrc39	dph5	ENSTRUP00000021291	ENSTRUP00000059624	Leucine rich repeat containing 39.	Diphthamide biosynthesis 5.	0.600
lrrc39	rtca	ENSTRUP00000021291	ENSTRUP00000005628	Leucine rich repeat containing 39.	RNA 3'-terminal phosphate cyclase.	0.657

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022900

Electron transport chain

9 of 106

1.82

4.26

4.44e-13

GO:0006091

Generation of precursor metabolites and energy

10 of 179

1.63

3.57

3.75e-13

GO:0045333

Cellular respiration

5 of 72

1.73

2.28

3.54e-06

GO:0006119

Oxidative phosphorylation

3 of 23

2.0

1.68

0.00047

GO:0022904

Respiratory electron transport chain

3 of 28

1.92

1.56

0.00072

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

7 of 26

2.32

5.51

2.01e-12

GO:0015078

Proton transmembrane transporter activity

7 of 27

2.3

5.48

2.01e-12

GO:0004129

Cytochrome-c oxidase activity

5 of 5

2.89

5.48

5.76e-11

GO:0009055

Electron transfer activity

8 of 63

1.99

4.69

2.01e-12

GO:0022853

Active ion transmembrane transporter activity

7 of 51

2.03

4.41

3.50e-11

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070469

Respirasome

6 of 13

2.55

5.77

3.70e-12

GO:0016021

Integral component of membrane

9 of 1572

0.65

0.54

0.00039

GO:0005886

Plasma membrane

11 of 2329

0.56

0.49

5.25e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1799

Mixed, incl. Cytochrome-c oxidase activity, and Ubiquinol-cytochrome-c reductase activity

10 of 14

2.74

10.91

7.47e-23

CL:1816

Respiratory chain, and Acid phosphatase activity

5 of 5

2.89

5.45

6.55e-11

CL:1802

Respirasome

4 of 5

2.79

4.0

3.58e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

8 of 86

1.86

4.19

3.86e-12

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

7 of 18

2.48

6.38

8.90e-14

GOCC:0016020

Membrane

10 of 1511

0.71

0.64

5.43e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0679

Respiratory chain

3 of 3

2.89

2.79

7.75e-06

KW-0186

Copper

2 of 4

2.59

1.65

0.00091

KW-0349

Heme

3 of 45

1.71

1.42

0.00093

KW-1133

Transmembrane helix

10 of 1742

0.65

0.56

9.70e-05

KW-1003

Cell membrane

4 of 402

0.89

0.5

0.0346

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00115

Cytochrome C and Quinol oxidase polypeptide I

2 of 2

2.89

1.14

0.0086

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