Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ube3cUbiquitin protein ligase E3C. (1150 aa)    
Predicted Functional Partners:
psmd14
Proteasome 26S subunit, non-ATPase 14.
   
 
 0.944
psmd2
26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.
    
 
 0.935
LOC101070351
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.886
LOC105417201
Proteasome 26S subunit, non-ATPase 4a.
    
 
 0.868
LOC101067241
Proteasome 26S subunit, non-ATPase 4b.
    
 
 0.868
trip12
Thyroid hormone receptor interactor 12.
     
 0.862
ADRM1
Adhesion regulating molecule 1.
    
 
 0.818
psmd6
Proteasome 26S subunit, non-ATPase 6.
   
 
 0.790
LOC101062380
Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family.
    
 
 0.781
usp14
Ubiquitin carboxyl-terminal hydrolase.
    
 
 0.766
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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