Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
smad7Mothers against decapentaplegic homolog. (373 aa)    
Predicted Functional Partners:
SMURF2
E3 ubiquitin-protein ligase.
    
 0.989
LOC101071114
E3 ubiquitin-protein ligase.
    
 0.989
SMURF1
SMAD specific E3 ubiquitin protein ligase 1.
    
 0.986
smad1
Mothers against decapentaplegic homolog.
    
0.967
LOC101064562
Mothers against decapentaplegic homolog.
    
0.967
smad9
Mothers against decapentaplegic homolog.
    
0.960
LOC101072871
Mothers against decapentaplegic homolog.
    
0.960
smad6
Mothers against decapentaplegic homolog.
  
  
0.905
LOC101078620
Mothers against decapentaplegic homolog.
     
 
0.900
smad3
Mothers against decapentaplegic homolog.
    
0.833
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.