STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IER5L-2Immediate early response 5 like. (293 aa)    
Predicted Functional Partners:
dusp10
Dual specificity phosphatase 10.
      
 0.580
socs2
Suppressor of cytokine signaling 2.
      
 0.569
ENSTRUP00000085642
Suppressor of cytokine signaling 2.
      
 0.569
JUND
BZIP domain-containing protein.
   
  
 0.456
LOC101076843
JunD proto-oncogene, AP-1 transcription factor subunit.
   
  
 0.456
fosl2
Fos-like antigen 2.
      
 0.450
dusp1
Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.
      
 0.430
egr1
Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.
      
 0.426
naa25
N(alpha)-acetyltransferase 25, NatB auxiliary subunit.
      
 0.416
phax
Phosphorylated adaptor for RNA export.
      
 0.404
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.