Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
slc14a1Urea transporter; Belongs to the urea transporter family. (476 aa)    
Predicted Functional Partners:
ace
Angiotensin-converting enzyme.
      
 0.760
aqp8
Aquaporin 8b; Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
  
 0.704
prkn
Ubiquitin-like domain-containing protein.
      
 0.700
rhbg
Ammonium transporter Rh type B; Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
      
 0.677
rhag
Rhesus-associated glycoprotein; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
      
 0.656
medag
Uncharacterized protein.
      
 0.621
atp6v1f
V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
    
   0.602
f2
Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.
      
 0.597
tmem97
Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
    
 
 0.593
sord
Sorbitol dehydrogenase.
      
 0.591
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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