Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
map3k3Mitogen-activated protein kinase kinase kinase 3. (632 aa)    
Predicted Functional Partners:
PAK2
Non-specific serine/threonine protein kinase.
  
 
0.940
pak1
Non-specific serine/threonine protein kinase.
    
0.936
pak2
Non-specific serine/threonine protein kinase.
    
0.936
MAP2K6
Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.
  
 
0.919
LOC101064673
Mitogen-activated protein kinase kinase 6.
  
 
0.918
map3k2
Mitogen-activated protein kinase kinase kinase 2.
  
 
 
0.904
LOC101061953
Mitogen-activated protein kinase kinase kinase 22.
  
  
 
0.902
traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.879
ccm2
CCM2 scaffold protein.
    
 0.821
smyd3
Uncharacterized protein.
    
 
 0.802
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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