STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APPAmyloid beta precursor protein. (780 aa)    
Predicted Functional Partners:
sorl1
Fibronectin type-III domain-containing protein.
    
 0.900
NCSTN
Nicastrin.
    
 0.869
ide
Insulin-degrading enzyme; Belongs to the peptidase M16 family.
    
 
 0.854
tnfrsf21
Tumor necrosis factor receptor superfamily, member 21.
    
 
 0.844
apoe2
Apolipoprotein E2.
    
 0.800
pitrm1
Pitrilysin metallopeptidase 1.
    
 
 0.780
SNCA
Uncharacterized protein; Belongs to the synuclein family.
   
 0.752
bace2
Beta-secretase 2; Belongs to the peptidase A1 family.
    
 0.710
bace1
Beta-secretase 1; Belongs to the peptidase A1 family.
    
 0.710
psenen
Presenilin enhancer, gamma-secretase subunit.
    
 0.708
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.