Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
cyp17a2Uncharacterized protein; Belongs to the cytochrome P450 family. (544 aa)    
Predicted Functional Partners:
hsd17b1
Hydroxysteroid (17-beta) dehydrogenase 1.
   
 0.962
hsd3b1
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family.
   
 0.962
LOC101075863
Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family.
  
0.960
hsd17b3
Hydroxysteroid (17-beta) dehydrogenase 3.
   
 0.959
LOC101063139
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
  
0.957
pfcyp19a
Uncharacterized protein; Belongs to the cytochrome P450 family.
  
0.956
LOC101072347
Hydroxysteroid (20-beta) dehydrogenase 2.
   
 0.950
LOC101067779
Hydroxysteroid (17-beta) dehydrogenase 12a; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 0.948
LOC101069556
Cytochrome P450, family 7, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family.
  
 
 0.947
LOC101067951
Uncharacterized protein; Belongs to the cytochrome P450 family.
  
0.942
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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