six6 protein (Takifugu rubripes) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

six6

SIX homeobox 6a. (245 aa)

Predicted Functional Partners:

eya3

0.573

LOC101079015

0.573

eya4

0.573

eya1

0.573

ppm1a

0.530

lhx2

0.521

pax6

0.499

Sox2

0.471

hoxd4a

0.467

LOC101066235

0.424

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101066235	six6	ENSTRUP00000048387	ENSTRUP00000026677	Transcription factor Sox1b.	SIX homeobox 6a.	0.424
LOC101079015	eya3	ENSTRUP00000034935	ENSTRUP00000029556	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.470
LOC101079015	six6	ENSTRUP00000034935	ENSTRUP00000026677	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 6a.	0.573
Sox2	pax6	ENSTRUP00000011608	ENSTRUP00000085114	SRY-box transcription factor 2.	Paired box 6b.	0.558
Sox2	six6	ENSTRUP00000011608	ENSTRUP00000026677	SRY-box transcription factor 2.	SIX homeobox 6a.	0.471
eya1	eya3	ENSTRUP00000087800	ENSTRUP00000029556	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.473
eya1	six6	ENSTRUP00000087800	ENSTRUP00000026677	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 6a.	0.573
eya3	LOC101079015	ENSTRUP00000029556	ENSTRUP00000034935	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.470
eya3	eya1	ENSTRUP00000029556	ENSTRUP00000087800	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.473
eya3	eya4	ENSTRUP00000029556	ENSTRUP00000087636	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog 4; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity); B [...]	0.472
eya3	six6	ENSTRUP00000029556	ENSTRUP00000026677	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 6a.	0.573
eya4	eya3	ENSTRUP00000087636	ENSTRUP00000029556	Eyes absent homolog 4; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity); B [...]	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.472
eya4	six6	ENSTRUP00000087636	ENSTRUP00000026677	Eyes absent homolog 4; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity); B [...]	SIX homeobox 6a.	0.573
hoxd4a	six6	ENSTRUP00000049251	ENSTRUP00000026677	Homeobox protein Hox-D4a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Deformed subfamily.	SIX homeobox 6a.	0.467
lhx2	six6	ENSTRUP00000003187	ENSTRUP00000026677	LIM homeobox 2b.	SIX homeobox 6a.	0.521
pax6	Sox2	ENSTRUP00000085114	ENSTRUP00000011608	Paired box 6b.	SRY-box transcription factor 2.	0.558
pax6	six6	ENSTRUP00000085114	ENSTRUP00000026677	Paired box 6b.	SIX homeobox 6a.	0.499
ppm1a	six6	ENSTRUP00000048498	ENSTRUP00000026677	Protein phosphatase, Mg2+/Mn2+ dependent, 1Aa.	SIX homeobox 6a.	0.530
six6	LOC101066235	ENSTRUP00000026677	ENSTRUP00000048387	SIX homeobox 6a.	Transcription factor Sox1b.	0.424
six6	LOC101079015	ENSTRUP00000026677	ENSTRUP00000034935	SIX homeobox 6a.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.573