six6 protein (Takifugu rubripes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

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experimentally determined

co-expression

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gene neighborhood

gene co-occurrence

gene fusions

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[Homology]

Score

six6

SIX homeobox 6a. (245 aa)

Predicted Functional Partners:

eya3

0.578

LOC101079015

0.578

eya4

0.578

eya1

0.578

ppm1a

0.571

lhx2

0.505

pax6

0.488

dlx1

0.462

pax5-2

0.445

vgll3

0.444

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101079015	six6	ENSTRUP00000034935	ENSTRUP00000026677	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 6a.	0.578
dlx1	lhx2	ENSTRUP00000045482	ENSTRUP00000003187	Distal-less homeobox 1a.	LIM homeobox 2b.	0.405
dlx1	six6	ENSTRUP00000045482	ENSTRUP00000026677	Distal-less homeobox 1a.	SIX homeobox 6a.	0.462
eya1	six6	ENSTRUP00000087800	ENSTRUP00000026677	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 6a.	0.578
eya3	six6	ENSTRUP00000029556	ENSTRUP00000026677	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 6a.	0.578
eya4	six6	ENSTRUP00000087636	ENSTRUP00000026677	Eyes absent homolog 4; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity); B [...]	SIX homeobox 6a.	0.578
lhx2	dlx1	ENSTRUP00000003187	ENSTRUP00000045482	LIM homeobox 2b.	Distal-less homeobox 1a.	0.405
lhx2	six6	ENSTRUP00000003187	ENSTRUP00000026677	LIM homeobox 2b.	SIX homeobox 6a.	0.505
pax5-2	six6	ENSTRUP00000058910	ENSTRUP00000026677	Paired domain-containing protein.	SIX homeobox 6a.	0.445
pax6	six6	ENSTRUP00000085114	ENSTRUP00000026677	Paired box 6b.	SIX homeobox 6a.	0.488
ppm1a	six6	ENSTRUP00000048498	ENSTRUP00000026677	Protein phosphatase, Mg2+/Mn2+ dependent, 1Aa.	SIX homeobox 6a.	0.571
six6	LOC101079015	ENSTRUP00000026677	ENSTRUP00000034935	SIX homeobox 6a.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.578
six6	dlx1	ENSTRUP00000026677	ENSTRUP00000045482	SIX homeobox 6a.	Distal-less homeobox 1a.	0.462
six6	eya1	ENSTRUP00000026677	ENSTRUP00000087800	SIX homeobox 6a.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.578
six6	eya3	ENSTRUP00000026677	ENSTRUP00000029556	SIX homeobox 6a.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.578
six6	eya4	ENSTRUP00000026677	ENSTRUP00000087636	SIX homeobox 6a.	Eyes absent homolog 4; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity); B [...]	0.578
six6	lhx2	ENSTRUP00000026677	ENSTRUP00000003187	SIX homeobox 6a.	LIM homeobox 2b.	0.505
six6	pax5-2	ENSTRUP00000026677	ENSTRUP00000058910	SIX homeobox 6a.	Paired domain-containing protein.	0.445
six6	pax6	ENSTRUP00000026677	ENSTRUP00000085114	SIX homeobox 6a.	Paired box 6b.	0.488
six6	ppm1a	ENSTRUP00000026677	ENSTRUP00000048498	SIX homeobox 6a.	Protein phosphatase, Mg2+/Mn2+ dependent, 1Aa.	0.571