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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
upf3bUPF3B regulator of nonsense mediated mRNA decay. (452 aa)    
Predicted Functional Partners:
UPF2
UPF2 regulator of nonsense mediated mRNA decay.
   
 0.998
LOC101074452
Mago homolog, exon junction complex subunit.
    
 0.993
LOC101064659
Uncharacterized protein.
    
 0.990
UPF1
Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).
    
 0.990
nxf1
Zgc:153681.
    
 0.975
smg5
SMG5 nonsense mediated mRNA decay factor.
   
 0.970
smg6
SMG6 nonsense mediated mRNA decay factor.
   
 0.945
eif4a3
Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family.
   
 0.944
rbm8a
RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
    
 0.936
srrm1
Serine/arginine repetitive matrix 1.
    
 0.918
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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