Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HPS6HPS6 biogenesis of lysosomal organelles complex 2 subunit 3. (916 aa)    
Predicted Functional Partners:
hps5
Uncharacterized protein.
    
 0.989
hps3
Hermansky-Pudlak syndrome 3 protein isoform X1.
   
 
 0.983
hps4
HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.
     
 0.947
appbp2
Amyloid beta precursor protein (cytoplasmic tail) binding protein 2.
      
 0.880
bloc1s3
Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). Belongs to the BLOC1S3 family.
     
 0.878
LOC101069067
Biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino.
     
 0.874
dtnbp1
Dystrobrevin binding protein 1b.
     
 0.873
bloc1s6
Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]
     
 0.869
hps1
HPS1 biogenesis of lysosomal organelles complex 3 subunit 1.
     
 0.855
dct
Dopachrome tautomerase.
      
 0.763
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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