LOC101079452 protein (Takifugu rubripes) - STRING interaction network

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Score

LOC101079452

Cyclin-dependent kinase 5 activator. (340 aa)

Predicted Functional Partners:

cdk5

0.917

astn1

0.727

LOC101079595

0.621

nrp1

0.496

tp73

0.451

tp63

0.451

LOC101077059

0.428

golga2

0.420

LOC101079928

0.403

fyn

0.403

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101077059	LOC101079452	ENSTRUP00000048623	ENSTRUP00000027786	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Cyclin-dependent kinase 5 activator.	0.428
LOC101077059	LOC101079595	ENSTRUP00000048623	ENSTRUP00000030644	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.830
LOC101077059	cdk5	ENSTRUP00000048623	ENSTRUP00000009566	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Cyclin-dependent kinase 5.	0.898
LOC101079452	LOC101077059	ENSTRUP00000027786	ENSTRUP00000048623	Cyclin-dependent kinase 5 activator.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.428
LOC101079452	LOC101079595	ENSTRUP00000027786	ENSTRUP00000030644	Cyclin-dependent kinase 5 activator.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.621
LOC101079452	LOC101079928	ENSTRUP00000027786	ENSTRUP00000002602	Cyclin-dependent kinase 5 activator.	Tyrosine-protein kinase.	0.403
LOC101079452	astn1	ENSTRUP00000027786	ENSTRUP00000064250	Cyclin-dependent kinase 5 activator.	Astrotactin 1.	0.727
LOC101079452	cdk5	ENSTRUP00000027786	ENSTRUP00000009566	Cyclin-dependent kinase 5 activator.	Cyclin-dependent kinase 5.	0.917
LOC101079452	fyn	ENSTRUP00000027786	ENSTRUP00000008304	Cyclin-dependent kinase 5 activator.	Tyrosine-protein kinase.	0.403
LOC101079452	golga2	ENSTRUP00000027786	ENSTRUP00000088096	Cyclin-dependent kinase 5 activator.	Golgin A2.	0.420
LOC101079452	nrp1	ENSTRUP00000027786	ENSTRUP00000068935	Cyclin-dependent kinase 5 activator.	Neuropilin; Belongs to the neuropilin family.	0.496
LOC101079452	tp63	ENSTRUP00000027786	ENSTRUP00000074614	Cyclin-dependent kinase 5 activator.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.451
LOC101079452	tp73	ENSTRUP00000027786	ENSTRUP00000070364	Cyclin-dependent kinase 5 activator.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.451
LOC101079595	LOC101077059	ENSTRUP00000030644	ENSTRUP00000048623	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.830
LOC101079595	LOC101079452	ENSTRUP00000030644	ENSTRUP00000027786	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Cyclin-dependent kinase 5 activator.	0.621
LOC101079595	LOC101079928	ENSTRUP00000030644	ENSTRUP00000002602	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Tyrosine-protein kinase.	0.430
LOC101079595	cdk5	ENSTRUP00000030644	ENSTRUP00000009566	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Cyclin-dependent kinase 5.	0.973
LOC101079595	fyn	ENSTRUP00000030644	ENSTRUP00000008304	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Tyrosine-protein kinase.	0.430
LOC101079595	tp63	ENSTRUP00000030644	ENSTRUP00000074614	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.919
LOC101079595	tp73	ENSTRUP00000030644	ENSTRUP00000070364	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.919