Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC101068919SIX homeobox 5. (901 aa)    
Predicted Functional Partners:
eya3
Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.
   
 0.710
LOC101079015
Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.
   
 0.708
eya4
Eyes absent homolog 4; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity); B [...]
   
 0.708
eya1
Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.
   
 0.708
LOC101077945
DM1 locus, WD repeat containing.
      
 0.631
batf
Basic leucine zipper transcription factor, ATF-like.
      
 0.540
snai2
Snail family zinc finger 2.
    
 
 0.492
JUND
BZIP domain-containing protein.
      
 0.462
LOC101076843
JunD proto-oncogene, AP-1 transcription factor subunit.
      
 0.462
usf1
Upstream transcription factor 1.
      
 0.459
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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