Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
Experiments
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[Homology]
Score
ccnjCyclin J; Belongs to the cyclin family. (362 aa)    
Predicted Functional Partners:
cdc6
Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.
   
 0.801
ENSTRUP00000024049
CDC28 protein kinase regulatory subunit 2.
   
 0.775
cks1b
Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
   
 0.775
orc1
Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
   
 0.756
skp2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase.
   
 0.748
skp1
S-phase kinase-associated protein 1; Belongs to the SKP1 family.
    
 0.739
LOC101065671
Cyclin N-terminal domain containing 2; Belongs to the cyclin family.
   
 0.738
LOC101068442
G2/mitotic-specific cyclin-B2-like.
   
 0.738
mad2l1
MAD2 mitotic arrest deficient-like 1 (yeast).
   
 0.715
LOC115246432
Chromatin licensing and DNA replication factor 1.
   
 0.698
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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