Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
irf7Interferon regulatory factor 7. (469 aa)    
Predicted Functional Partners:
traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.998
LOC101071639
Interferon regulatory factor 3.
   
0.997
LOC101061773
Interleukin-1 receptor-associated kinase 1.
    
 0.985
myd88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
   
 0.981
ikbke
Protein kinase domain-containing protein.
    
 0.974
LOC101068225
Component of inhibitor of nuclear factor kappa B kinase complex.
    
 0.955
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
    
 0.945
ticam
Toll-like receptor adaptor molecule.
    
 0.940
rsad2
Radical S-adenosyl methionine domain containing 2.
   
 
 0.907
LOC101069645
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
    
 0.907
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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