sfmbt2 protein (Takifugu rubripes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

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Coexpression

Experiments

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[Homology]

Score

sfmbt2

Scm like with four mbt domains 2. (899 aa)

Predicted Functional Partners:

rnf2

0.629

azi2

0.592

blvrb

0.567

ndufaf6

0.567

rybp

0.533

LOC101070310

0.533

YAF2

0.533

tfdp1

0.470

setd7

0.451

EZH1

0.451

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EZH1	rnf2	ENSTRUP00000038365	ENSTRUP00000056662	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	Ring finger protein 2.	0.873
EZH1	sfmbt2	ENSTRUP00000038365	ENSTRUP00000029749	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	Scm like with four mbt domains 2.	0.451
EZH1	tfdp1	ENSTRUP00000038365	ENSTRUP00000033270	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	Transcription factor.	0.629
LOC101070310	rnf2	ENSTRUP00000042934	ENSTRUP00000056662	YY1 associated factor 2.	Ring finger protein 2.	0.928
LOC101070310	sfmbt2	ENSTRUP00000042934	ENSTRUP00000029749	YY1 associated factor 2.	Scm like with four mbt domains 2.	0.533
LOC101070310	tfdp1	ENSTRUP00000042934	ENSTRUP00000033270	YY1 associated factor 2.	Transcription factor.	0.631
YAF2	rnf2	ENSTRUP00000042976	ENSTRUP00000056662	YY1 associated factor 2.	Ring finger protein 2.	0.928
YAF2	sfmbt2	ENSTRUP00000042976	ENSTRUP00000029749	YY1 associated factor 2.	Scm like with four mbt domains 2.	0.533
YAF2	tfdp1	ENSTRUP00000042976	ENSTRUP00000033270	YY1 associated factor 2.	Transcription factor.	0.631
azi2	blvrb	ENSTRUP00000061700	ENSTRUP00000009680	5-azacytidine induced 2.	Biliverdin reductase B.	0.767
azi2	ndufaf6	ENSTRUP00000061700	ENSTRUP00000018077	5-azacytidine induced 2.	NADH:ubiquinone oxidoreductase complex assembly factor 6.	0.820
azi2	sfmbt2	ENSTRUP00000061700	ENSTRUP00000029749	5-azacytidine induced 2.	Scm like with four mbt domains 2.	0.592
blvrb	azi2	ENSTRUP00000009680	ENSTRUP00000061700	Biliverdin reductase B.	5-azacytidine induced 2.	0.767
blvrb	ndufaf6	ENSTRUP00000009680	ENSTRUP00000018077	Biliverdin reductase B.	NADH:ubiquinone oxidoreductase complex assembly factor 6.	0.807
blvrb	sfmbt2	ENSTRUP00000009680	ENSTRUP00000029749	Biliverdin reductase B.	Scm like with four mbt domains 2.	0.567
ndufaf6	azi2	ENSTRUP00000018077	ENSTRUP00000061700	NADH:ubiquinone oxidoreductase complex assembly factor 6.	5-azacytidine induced 2.	0.820
ndufaf6	blvrb	ENSTRUP00000018077	ENSTRUP00000009680	NADH:ubiquinone oxidoreductase complex assembly factor 6.	Biliverdin reductase B.	0.807
ndufaf6	sfmbt2	ENSTRUP00000018077	ENSTRUP00000029749	NADH:ubiquinone oxidoreductase complex assembly factor 6.	Scm like with four mbt domains 2.	0.567
rnf2	EZH1	ENSTRUP00000056662	ENSTRUP00000038365	Ring finger protein 2.	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	0.873
rnf2	LOC101070310	ENSTRUP00000056662	ENSTRUP00000042934	Ring finger protein 2.	YY1 associated factor 2.	0.928

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.907

expected number of edges:

10

PPI enrichment p-value:

5.55e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030042

Actin filament depolymerization

3 of 11

2.71

1.91

0.00032

GO:0051014

Actin filament severing

3 of 16

2.55

1.85

0.00038

GO:0030043

Actin filament fragmentation

2 of 3

3.1

1.37

0.0034

GO:0030036

Actin cytoskeleton organization

6 of 512

1.35

1.27

0.00038

GO:0022604

Regulation of cell morphogenesis

4 of 196

1.59

1.14

0.0034

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003779

Actin binding

5 of 498

1.28

0.85

0.0087

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015629

Actin cytoskeleton

5 of 376

1.4

1.19

0.0011

GO:0005925

Focal adhesion

3 of 112

1.7

0.97

0.0109

GO:0005856

Cytoskeleton

7 of 1877

0.85

0.6

0.0073

GO:0043232

Intracellular non-membrane-bounded organelle

8 of 3620

0.62

0.4

0.0212

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2568

ADF/Cofilin, and Sema3A PAK dependent Axon repulsion

3 of 6

2.98

2.42

4.03e-05

CL:2418

Mixed, incl. Dual specificity phosphatase, catalytic domain, and MAP kinase activity

4 of 89

1.93

1.83

0.00018

CL:1933

Parvin, and Integrin-linked protein kinase, pseudokinase domain

2 of 7

2.73

1.2

0.0067

CL:1398

Mixed, incl. Phenylalanine zipper, and Insulin receptor, trans-membrane domain

2 of 8

2.67

1.18

0.0071

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-446388

Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

3 of 11

2.71

2.27

6.62e-05

MAP-9020591

Interleukin-12 signaling

3 of 15

2.58

2.23

7.41e-05

MAP-447115

Interleukin-12 family signaling

3 of 21

2.43

2.09

0.00012

MAP-399954

Sema3A PAK dependent Axon repulsion

3 of 26

2.34

1.99

0.00017

MAP-446353

Cell-extracellular matrix interactions

3 of 32

2.25

1.89

0.00024

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0009

Actin-binding

3 of 120

1.67

0.97

0.0106

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017904

ADF/Cofilin

3 of 3

3.28

2.67

1.53e-05

IPR002108

Actin-depolymerising factor homology domain

3 of 12

2.67

2.05

0.00017

IPR029006

ADF-H/Gelsolin-like domain superfamily

3 of 30

2.28

1.52

0.0014

IPR028433

Parvin

2 of 3

3.1

1.31

0.0044

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00102

Actin depolymerisation factor/cofilin -like domains

3 of 11

2.71

2.45

3.06e-05

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