LOC101070002 protein (Takifugu rubripes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

LOC101070002

Smith-Magenis syndrome chromosome region, candidate 8b. (654 aa)

Predicted Functional Partners:

wdr41

0.971

c9orf72

0.957

LOC101076837

0.921

ulk1

0.921

ulk2

0.918

LOC101078682

0.911

tank

0.911

ENSTRUP00000086078

0.798

LOC101063247

0.698

RAB8A

0.698

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSTRUP00000086078	LOC101070002	ENSTRUP00000086078	ENSTRUP00000034255	annotation not available	Smith-Magenis syndrome chromosome region, candidate 8b.	0.798
ENSTRUP00000086078	LOC101078682	ENSTRUP00000086078	ENSTRUP00000015296	annotation not available	Smith-Magenis syndrome chromosome region, candidate 8a.	0.798
ENSTRUP00000086078	wdr41	ENSTRUP00000086078	ENSTRUP00000046860	annotation not available	WD repeat domain 41.	0.922
LOC101063247	LOC101070002	ENSTRUP00000049701	ENSTRUP00000034255	RAB8A, member RAS oncogene family.	Smith-Magenis syndrome chromosome region, candidate 8b.	0.698
LOC101063247	LOC101078682	ENSTRUP00000049701	ENSTRUP00000015296	RAB8A, member RAS oncogene family.	Smith-Magenis syndrome chromosome region, candidate 8a.	0.698
LOC101063247	RAB8A	ENSTRUP00000049701	ENSTRUP00000081510	RAB8A, member RAS oncogene family.	RAB8A, member RAS oncogene family.	0.900
LOC101063247	c9orf72	ENSTRUP00000049701	ENSTRUP00000002461	RAB8A, member RAS oncogene family.	Zgc:100846.	0.696
LOC101063247	wdr41	ENSTRUP00000049701	ENSTRUP00000046860	RAB8A, member RAS oncogene family.	WD repeat domain 41.	0.720
LOC101070002	ENSTRUP00000086078	ENSTRUP00000034255	ENSTRUP00000086078	Smith-Magenis syndrome chromosome region, candidate 8b.	annotation not available	0.798
LOC101070002	LOC101063247	ENSTRUP00000034255	ENSTRUP00000049701	Smith-Magenis syndrome chromosome region, candidate 8b.	RAB8A, member RAS oncogene family.	0.698
LOC101070002	LOC101076837	ENSTRUP00000034255	ENSTRUP00000029853	Smith-Magenis syndrome chromosome region, candidate 8b.	Unc-51 like autophagy activating kinase 1a.	0.921
LOC101070002	LOC101078682	ENSTRUP00000034255	ENSTRUP00000015296	Smith-Magenis syndrome chromosome region, candidate 8b.	Smith-Magenis syndrome chromosome region, candidate 8a.	0.911
LOC101070002	RAB8A	ENSTRUP00000034255	ENSTRUP00000081510	Smith-Magenis syndrome chromosome region, candidate 8b.	RAB8A, member RAS oncogene family.	0.698
LOC101070002	c9orf72	ENSTRUP00000034255	ENSTRUP00000002461	Smith-Magenis syndrome chromosome region, candidate 8b.	Zgc:100846.	0.957
LOC101070002	tank	ENSTRUP00000034255	ENSTRUP00000053493	Smith-Magenis syndrome chromosome region, candidate 8b.	TBD domain-containing protein.	0.911
LOC101070002	ulk1	ENSTRUP00000034255	ENSTRUP00000068366	Smith-Magenis syndrome chromosome region, candidate 8b.	Serine/threonine-protein kinase ULK1 isoform X1.	0.921
LOC101070002	ulk2	ENSTRUP00000034255	ENSTRUP00000058225	Smith-Magenis syndrome chromosome region, candidate 8b.	Unc-51 like autophagy activating kinase 2.	0.918
LOC101070002	wdr41	ENSTRUP00000034255	ENSTRUP00000046860	Smith-Magenis syndrome chromosome region, candidate 8b.	WD repeat domain 41.	0.971
LOC101076837	LOC101070002	ENSTRUP00000029853	ENSTRUP00000034255	Unc-51 like autophagy activating kinase 1a.	Smith-Magenis syndrome chromosome region, candidate 8b.	0.921
LOC101076837	LOC101078682	ENSTRUP00000029853	ENSTRUP00000015296	Unc-51 like autophagy activating kinase 1a.	Smith-Magenis syndrome chromosome region, candidate 8a.	0.921

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Network Stats

number of nodes:

8

number of edges:

18

average node degree:

4.5

avg. local clustering coefficient:

0.624

expected number of edges:

7

PPI enrichment p-value:

0.000379

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003383

Apical constriction

3 of 4

3.15

2.49

3.06e-05

GO:0031032

Actomyosin structure organization

3 of 103

1.74

0.76

0.0328

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20317

Cadherin conserved site, and Plakophilin/Delta catenin

5 of 70

2.13

2.91

1.06e-06

CL:9807

Atrophin-like, and c4 zinc finger in nuclear hormone receptors

3 of 6

2.98

2.87

5.76e-06

CL:20400

Mixed, incl. Limb expression 1, and Retina layer formation

3 of 10

2.75

2.66

1.25e-05

CL:6889

Mixed, incl. FERM domain-containing protein 6-like, and WWC, C2 domain

3 of 12

2.67

2.56

1.82e-05

CL:20403

Limb expression 1, and Retina layer formation

2 of 5

2.88

1.61

0.0012

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04392

Hippo signaling pathway - multiple species

4 of 78

1.99

2.33

1.41e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8943724

Regulation of PTEN gene transcription

3 of 68

1.92

1.03

0.0102

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098592

Cytoplasmic side of apical plasma membrane

3 of 5

3.05

2.77

9.20e-06

GOCC:0035003

Subapical complex

2 of 5

2.88

1.51

0.0018

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03154

Atrophin-1 family

3 of 3

3.28

2.94

4.75e-06

PF14954

Limb expression 1

2 of 2

3.28

1.55

0.0016

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR047145

FERM domain-containing protein 6-like

3 of 3

3.28

2.67

1.53e-05

IPR002951

Atrophin-like

3 of 3

3.28

2.67

1.53e-05

IPR029270

Limb expression 1

2 of 2

3.28

1.49

0.0021

IPR018980

FERM, C-terminal PH-like domain

3 of 35

2.21

1.43

0.0020

IPR018979

FERM, N-terminal

3 of 34

2.22

1.43

0.0020

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01196

FERM C-terminal PH-like domain

3 of 35

2.21

1.66

0.00070

SM00295

Band 4.1 homologues

3 of 64

1.95

1.37

0.0020

SM01189

The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex PUBMED:10226007. The domain is usually found to the N terminus of a myb-like DNA binding domain SANT ...

2 of 11

2.54

1.26

0.0050

SM00717

SANT SWI3, ADA2, N-CoR and TFIIIB DNA-binding domains

2 of 44

1.93

0.69

0.0498

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