atr protein (Takifugu rubripes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Fancm	atm	ENSTRUP00000024507	ENSTRUP00000088348	ERCC4 domain-containing protein.	TAN domain-containing protein.	0.780
Fancm	atr	ENSTRUP00000024507	ENSTRUP00000035419	ERCC4 domain-containing protein.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.996
Fancm	atrip	ENSTRUP00000024507	ENSTRUP00000008639	ERCC4 domain-containing protein.	Uncharacterized protein.	0.979
Fancm	brca1	ENSTRUP00000024507	ENSTRUP00000050269	ERCC4 domain-containing protein.	Uncharacterized protein.	0.893
Fancm	chek1	ENSTRUP00000024507	ENSTRUP00000043876	ERCC4 domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.651
Fancm	chek2	ENSTRUP00000024507	ENSTRUP00000035807	ERCC4 domain-containing protein.	Checkpoint kinase 2.	0.762
Fancm	hus1	ENSTRUP00000024507	ENSTRUP00000012193	ERCC4 domain-containing protein.	Checkpoint protein; Belongs to the HUS1 family.	0.818
Fancm	rad1	ENSTRUP00000024507	ENSTRUP00000073061	ERCC4 domain-containing protein.	RAD1 homolog (S. pombe).	0.861
Fancm	telo2	ENSTRUP00000024507	ENSTRUP00000038251	ERCC4 domain-containing protein.	TEL2, telomere maintenance 2, homolog (S. cerevisiae).	0.979
LOC101079595	atm	ENSTRUP00000030644	ENSTRUP00000088348	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	TAN domain-containing protein.	0.999
LOC101079595	atr	ENSTRUP00000030644	ENSTRUP00000035419	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.998
LOC101079595	atrip	ENSTRUP00000030644	ENSTRUP00000008639	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Uncharacterized protein.	0.711
LOC101079595	brca1	ENSTRUP00000030644	ENSTRUP00000050269	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Uncharacterized protein.	0.995
LOC101079595	chek1	ENSTRUP00000030644	ENSTRUP00000043876	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.999
LOC101079595	chek2	ENSTRUP00000030644	ENSTRUP00000035807	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Checkpoint kinase 2.	0.999
LOC101079595	hus1	ENSTRUP00000030644	ENSTRUP00000012193	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Checkpoint protein; Belongs to the HUS1 family.	0.643
LOC101079595	rad1	ENSTRUP00000030644	ENSTRUP00000073061	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	RAD1 homolog (S. pombe).	0.575
atm	Fancm	ENSTRUP00000088348	ENSTRUP00000024507	TAN domain-containing protein.	ERCC4 domain-containing protein.	0.780
atm	LOC101079595	ENSTRUP00000088348	ENSTRUP00000030644	TAN domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.999
atm	atr	ENSTRUP00000088348	ENSTRUP00000035419	TAN domain-containing protein.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.998