crtap protein (Takifugu rubripes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

crtap

Cartilage associated protein. (405 aa)

Predicted Functional Partners:

ppib

0.804

p3h1

0.671

p3h3

0.661

p3h2

0.661

ppic

0.644

LOC101063935

0.575

serpinh1

0.554

serpinf1

0.553

TMEM38B

0.550

ifitm5

0.528

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101063935	TMEM38B	ENSTRUP00000071507	ENSTRUP00000022301	Peptidylprolyl isomerase.	Transmembrane protein 38B.	0.539
LOC101063935	crtap	ENSTRUP00000071507	ENSTRUP00000035874	Peptidylprolyl isomerase.	Cartilage associated protein.	0.575
LOC101063935	ifitm5	ENSTRUP00000071507	ENSTRUP00000073605	Peptidylprolyl isomerase.	Interferon induced transmembrane protein 5.	0.509
LOC101063935	p3h1	ENSTRUP00000071507	ENSTRUP00000003144	Peptidylprolyl isomerase.	Prolyl 3-hydroxylase 1.	0.577
LOC101063935	ppib	ENSTRUP00000071507	ENSTRUP00000052493	Peptidylprolyl isomerase.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.504
LOC101063935	ppic	ENSTRUP00000071507	ENSTRUP00000050723	Peptidylprolyl isomerase.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.423
LOC101063935	serpinf1	ENSTRUP00000071507	ENSTRUP00000012928	Peptidylprolyl isomerase.	SERPIN domain-containing protein; Belongs to the serpin family.	0.667
LOC101063935	serpinh1	ENSTRUP00000071507	ENSTRUP00000003570	Peptidylprolyl isomerase.	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b; Belongs to the serpin family.	0.599
TMEM38B	LOC101063935	ENSTRUP00000022301	ENSTRUP00000071507	Transmembrane protein 38B.	Peptidylprolyl isomerase.	0.539
TMEM38B	crtap	ENSTRUP00000022301	ENSTRUP00000035874	Transmembrane protein 38B.	Cartilage associated protein.	0.550
TMEM38B	ifitm5	ENSTRUP00000022301	ENSTRUP00000073605	Transmembrane protein 38B.	Interferon induced transmembrane protein 5.	0.555
TMEM38B	p3h1	ENSTRUP00000022301	ENSTRUP00000003144	Transmembrane protein 38B.	Prolyl 3-hydroxylase 1.	0.541
TMEM38B	ppib	ENSTRUP00000022301	ENSTRUP00000052493	Transmembrane protein 38B.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.463
TMEM38B	serpinf1	ENSTRUP00000022301	ENSTRUP00000012928	Transmembrane protein 38B.	SERPIN domain-containing protein; Belongs to the serpin family.	0.528
TMEM38B	serpinh1	ENSTRUP00000022301	ENSTRUP00000003570	Transmembrane protein 38B.	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b; Belongs to the serpin family.	0.404
crtap	LOC101063935	ENSTRUP00000035874	ENSTRUP00000071507	Cartilage associated protein.	Peptidylprolyl isomerase.	0.575
crtap	TMEM38B	ENSTRUP00000035874	ENSTRUP00000022301	Cartilage associated protein.	Transmembrane protein 38B.	0.550
crtap	ifitm5	ENSTRUP00000035874	ENSTRUP00000073605	Cartilage associated protein.	Interferon induced transmembrane protein 5.	0.528
crtap	p3h1	ENSTRUP00000035874	ENSTRUP00000003144	Cartilage associated protein.	Prolyl 3-hydroxylase 1.	0.671
crtap	p3h2	ENSTRUP00000035874	ENSTRUP00000045245	Cartilage associated protein.	Prolyl 3-hydroxylase 2.	0.661

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

42

average node degree:

7.64

avg. local clustering coefficient:

0.671

expected number of edges:

13

PPI enrichment p-value:

2.58e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030433

Ubiquitin-dependent ERAD pathway

7 of 79

2.18

4.55

1.30e-10

GO:0006620

Post-translational protein targeting to endoplasmic reticulum membrane

4 of 15

2.66

3.5

2.71e-07

GO:0030970

Retrograde protein transport, ER to cytosol

4 of 20

2.53

3.3

5.49e-07

GO:0006886

Intracellular protein transport

9 of 676

1.36

2.03

2.26e-08

GO:0006511

Ubiquitin-dependent protein catabolic process

8 of 554

1.39

1.99

1.62e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0048408

Epidermal growth factor binding

4 of 6

3.06

4.02

4.41e-08

GO:0043022

Ribosome binding

5 of 81

2.02

2.77

1.33e-06

GO:0060090

Molecular adaptor activity

4 of 405

1.23

0.65

0.0306

GO:0044877

Protein-containing complex binding

6 of 1270

0.91

0.57

0.0183

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071256

Translocon complex

5 of 5

3.23

6.01

1.00e-11

GO:0031205

Endoplasmic reticulum Sec complex

4 of 4

3.23

4.63

3.74e-09

GO:0005784

Sec61 translocon complex

4 of 4

3.23

4.63

3.74e-09

GO:0044322

Endoplasmic reticulum quality control compartment

4 of 18

2.58

3.59

1.56e-07

GO:0072380

TRC complex

3 of 4

3.11

3.24

1.26e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18881

Oligosaccharyltransferase complex, and Translocon complex

5 of 30

2.45

3.86

3.05e-08

CL:11533

ER membrane insertion complex, and GET complex

3 of 12

2.63

2.35

4.53e-05

CL:18929

Post-translational protein targeting to membrane, translocation, and SecY

2 of 5

2.84

1.34

0.0038

CL:18883

Oligosaccharyltransferase complex, and Translocon-associated protein beta (TRAPB)

2 of 22

2.19

0.74

0.0430

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03060

Protein export

5 of 43

2.3

3.88

1.39e-08

map04145

Phagosome

5 of 236

1.56

1.81

2.50e-05

map04141

Protein processing in endoplasmic reticulum

5 of 336

1.41

1.48

9.33e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9609523

Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

11 of 35

2.73

12.55

8.76e-27

MAP-9609507

Protein localization

11 of 235

1.9

5.76

1.31e-18

MAP-1236974

ER-Phagosome pathway

5 of 119

1.86

2.46

2.95e-06

MAP-1236975

Antigen processing-Cross presentation

5 of 138

1.79

2.33

4.53e-06

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

5 of 356

1.38

1.3

0.00037

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0071256

Translocon complex

5 of 13

2.82

5.01

4.05e-10

GOCC:0005784

Sec61 translocon complex

4 of 12

2.76

3.81

7.71e-08

GOCC:0072380

TRC complex

2 of 2

3.23

1.81

0.00054

GOCC:0005789

Endoplasmic reticulum membrane

6 of 460

1.35

1.5

3.75e-05

GOCC:0005783

Endoplasmic reticulum

6 of 935

1.04

0.86

0.0014

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

5 of 44

2.29

3.81

1.90e-08

KW-0256

Endoplasmic reticulum

5 of 163

1.72

2.22

5.08e-06

KW-0802

TPR repeat

4 of 126

1.73

1.84

7.43e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03911

Sec61beta family

3 of 3

3.23

2.85

6.92e-06

PF16546

Homodimerisation domain of SGTA

2 of 2

3.23

1.48

0.0022

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00028

Tetratricopeptide repeats

3 of 93

1.74

0.89

0.0169

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About