STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] (1499 aa)    
Predicted Functional Partners:
LOC101063539
Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family.
    
 0.984
pdgfb
Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family.
   
 0.978
grb2
Growth factor receptor-bound protein 2b.
   
 0.967
LOC101061204
Uncharacterized protein.
   
 0.967
pdgfc
Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family.
    
 0.957
Pdgfd
Platelet derived growth factor d; Belongs to the PDGF/VEGF growth factor family.
    
 0.942
src
Tyrosine-protein kinase.
   
0.936
LOC101065281
Tyrosine-protein kinase.
   
0.936
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
    
 0.929
sos2
Son of sevenless homolog 2 (Drosophila).
    
 0.929
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.