gatb protein (Takifugu rubripes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

gatb

Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily. (551 aa)

Predicted Functional Partners:

dars2

0.999

qrsl1

0.999

faah2

0.994

LOC101078866

0.994

dars1

0.991

eprs1

0.977

gmps

0.951

LOC101066548

0.950

LOC101063617

0.923

slx4

0.914

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101063617	LOC101066548	ENSTRUP00000065930	ENSTRUP00000067312	Uncharacterized protein.	Asparagine--tRNA ligase, cytoplasmic-like isoform X1.	0.777
LOC101063617	LOC101078866	ENSTRUP00000065930	ENSTRUP00000045306	Uncharacterized protein.	Fatty acid amide hydrolase.	0.805
LOC101063617	dars1	ENSTRUP00000065930	ENSTRUP00000073662	Uncharacterized protein.	Aspartyl-tRNA synthetase.	0.777
LOC101063617	eprs1	ENSTRUP00000065930	ENSTRUP00000016942	Uncharacterized protein.	Glutamyl-prolyl-tRNA synthetase.	0.775
LOC101063617	faah2	ENSTRUP00000065930	ENSTRUP00000012902	Uncharacterized protein.	Fatty acid amide hydrolase 2b.	0.805
LOC101063617	gatb	ENSTRUP00000065930	ENSTRUP00000038937	Uncharacterized protein.	Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily.	0.923
LOC101063617	gmps	ENSTRUP00000065930	ENSTRUP00000066154	Uncharacterized protein.	Guanine monophosphate synthase.	0.829
LOC101063617	qrsl1	ENSTRUP00000065930	ENSTRUP00000085024	Uncharacterized protein.	Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the amidase family. GatA subfamily.	0.806
LOC101063617	slx4	ENSTRUP00000065930	ENSTRUP00000032108	Uncharacterized protein.	Uncharacterized protein.	0.777
LOC101066548	LOC101063617	ENSTRUP00000067312	ENSTRUP00000065930	Asparagine--tRNA ligase, cytoplasmic-like isoform X1.	Uncharacterized protein.	0.777
LOC101066548	LOC101078866	ENSTRUP00000067312	ENSTRUP00000045306	Asparagine--tRNA ligase, cytoplasmic-like isoform X1.	Fatty acid amide hydrolase.	0.752
LOC101066548	dars1	ENSTRUP00000067312	ENSTRUP00000073662	Asparagine--tRNA ligase, cytoplasmic-like isoform X1.	Aspartyl-tRNA synthetase.	0.452
LOC101066548	dars2	ENSTRUP00000067312	ENSTRUP00000017516	Asparagine--tRNA ligase, cytoplasmic-like isoform X1.	Aspartyl-tRNA synthetase 2, mitochondrial.	0.580
LOC101066548	eprs1	ENSTRUP00000067312	ENSTRUP00000016942	Asparagine--tRNA ligase, cytoplasmic-like isoform X1.	Glutamyl-prolyl-tRNA synthetase.	0.997
LOC101066548	faah2	ENSTRUP00000067312	ENSTRUP00000012902	Asparagine--tRNA ligase, cytoplasmic-like isoform X1.	Fatty acid amide hydrolase 2b.	0.752
LOC101066548	gatb	ENSTRUP00000067312	ENSTRUP00000038937	Asparagine--tRNA ligase, cytoplasmic-like isoform X1.	Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily.	0.950
LOC101066548	qrsl1	ENSTRUP00000067312	ENSTRUP00000085024	Asparagine--tRNA ligase, cytoplasmic-like isoform X1.	Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the amidase family. GatA subfamily.	0.976
LOC101078866	LOC101063617	ENSTRUP00000045306	ENSTRUP00000065930	Fatty acid amide hydrolase.	Uncharacterized protein.	0.805
LOC101078866	LOC101066548	ENSTRUP00000045306	ENSTRUP00000067312	Fatty acid amide hydrolase.	Asparagine--tRNA ligase, cytoplasmic-like isoform X1.	0.752
LOC101078866	dars1	ENSTRUP00000045306	ENSTRUP00000073662	Fatty acid amide hydrolase.	Aspartyl-tRNA synthetase.	0.752

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.886

expected number of edges:

11

PPI enrichment p-value:

6.15e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005978

Glycogen biosynthetic process

2 of 4

2.07

0.71

0.0478

GO:0005975

Carbohydrate metabolic process

6 of 135

1.02

0.7

0.0081

GO:0006096

Glycolytic process

2 of 8

1.77

0.68

0.0496

GO:0016051

Carbohydrate biosynthetic process

4 of 61

1.19

0.63

0.0327

GO:0034637

Cellular carbohydrate biosynthetic process

3 of 35

1.3

0.61

0.0478

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016757

Glycosyltransferase activity

5 of 71

1.22

0.91

0.0040

GO:0102752

1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)

2 of 2

2.37

0.87

0.0254

GO:0003844

1,4-alpha-glucan branching enzyme activity

2 of 2

2.37

0.87

0.0254

GO:0003824

Catalytic activity

11 of 1256

0.31

0.24

0.0489

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2578

Starch and sucrose metabolism, and Glycosyltransferase subfamily 4-like, N-terminal domain

6 of 25

1.75

2.59

4.44e-07

CL:2580

Mixed, incl. Starch and sucrose metabolism, and Phosphoglucosamine mutase activity

5 of 17

1.84

2.42

3.45e-06

CL:382

Glycolysis, and Aldehyde-lyase activity

3 of 5

2.15

1.9

0.00020

CL:2583

Mixed, incl. Glycogen metabolic process, and Trehalose-phosphatase

3 of 11

1.81

1.45

0.0010

CL:2475

Mixed, incl. Carbohydrate metabolic process, and Glycosyl transferases group 1

7 of 143

1.06

7.34e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00500

Starch and sucrose metabolism

3 of 17

1.62

1.04

0.0066

map00010

Glycolysis / Gluconeogenesis

3 of 26

1.43

0.96

0.0069

map01230

Biosynthesis of amino acids

3 of 57

1.09

0.58

0.0360

map01110

Biosynthesis of secondary metabolites

6 of 243

0.76

0.54

0.0069

map01200

Carbon metabolism

3 of 66

1.03

0.53

0.0449

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031588

Nucleotide-activated protein kinase complex

2 of 2

2.37

0.94

0.0191

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13439

Glycosyltransferase Family 4

3 of 13

1.73

0.98

0.0108

PF02922

Carbohydrate-binding module 48 (Isoamylase N-terminal domain)

2 of 3

2.19

0.87

0.0245

PF13692

Glycosyl transferases group 1

3 of 23

1.49

0.77

0.0245

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (14%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About