PAK3 protein (Takifugu rubripes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PAK3

Non-specific serine/threonine protein kinase. (575 aa)

Predicted Functional Partners:

LOC101067723

0.986

LOC101066462

0.975

nck2

0.973

nck1

0.973

LOC101068145

0.973

limk2

0.960

LOC101061585

0.949

LOC101074215

0.939

LOC101077791

0.923

map2k1

0.920

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101061585	LOC101077791	ENSTRUP00000027032	ENSTRUP00000080206	LIM domain kinase 1b.	Uncharacterized protein.	0.504
LOC101061585	PAK3	ENSTRUP00000027032	ENSTRUP00000042993	LIM domain kinase 1b.	Non-specific serine/threonine protein kinase.	0.949
LOC101061585	limk2	ENSTRUP00000027032	ENSTRUP00000065003	LIM domain kinase 1b.	LIM domain kinase 2.	0.906
LOC101066462	LOC101067723	ENSTRUP00000069148	ENSTRUP00000078989	Rho guanine nucleotide exchange factor (GEF) 7b.	Cell division cycle 42.	0.671
LOC101066462	LOC101068145	ENSTRUP00000069148	ENSTRUP00000080891	Rho guanine nucleotide exchange factor (GEF) 7b.	Uncharacterized protein.	0.624
LOC101066462	LOC101074215	ENSTRUP00000069148	ENSTRUP00000016657	Rho guanine nucleotide exchange factor (GEF) 7b.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.417
LOC101066462	LOC101077791	ENSTRUP00000069148	ENSTRUP00000080206	Rho guanine nucleotide exchange factor (GEF) 7b.	Uncharacterized protein.	0.856
LOC101066462	PAK3	ENSTRUP00000069148	ENSTRUP00000042993	Rho guanine nucleotide exchange factor (GEF) 7b.	Non-specific serine/threonine protein kinase.	0.975
LOC101066462	nck1	ENSTRUP00000069148	ENSTRUP00000045455	Rho guanine nucleotide exchange factor (GEF) 7b.	Cytoplasmic protein.	0.602
LOC101066462	nck2	ENSTRUP00000069148	ENSTRUP00000034543	Rho guanine nucleotide exchange factor (GEF) 7b.	Cytoplasmic protein.	0.602
LOC101067723	LOC101066462	ENSTRUP00000078989	ENSTRUP00000069148	Cell division cycle 42.	Rho guanine nucleotide exchange factor (GEF) 7b.	0.671
LOC101067723	LOC101068145	ENSTRUP00000078989	ENSTRUP00000080891	Cell division cycle 42.	Uncharacterized protein.	0.900
LOC101067723	LOC101074215	ENSTRUP00000078989	ENSTRUP00000016657	Cell division cycle 42.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.445
LOC101067723	LOC101077791	ENSTRUP00000078989	ENSTRUP00000080206	Cell division cycle 42.	Uncharacterized protein.	0.989
LOC101067723	PAK3	ENSTRUP00000078989	ENSTRUP00000042993	Cell division cycle 42.	Non-specific serine/threonine protein kinase.	0.986
LOC101067723	limk2	ENSTRUP00000078989	ENSTRUP00000065003	Cell division cycle 42.	LIM domain kinase 2.	0.585
LOC101067723	map2k1	ENSTRUP00000078989	ENSTRUP00000081797	Cell division cycle 42.	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.530
LOC101067723	nck1	ENSTRUP00000078989	ENSTRUP00000045455	Cell division cycle 42.	Cytoplasmic protein.	0.595
LOC101067723	nck2	ENSTRUP00000078989	ENSTRUP00000034543	Cell division cycle 42.	Cytoplasmic protein.	0.595
LOC101068145	LOC101066462	ENSTRUP00000080891	ENSTRUP00000069148	Uncharacterized protein.	Rho guanine nucleotide exchange factor (GEF) 7b.	0.624