STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101068749Proline-rich nuclear receptor coactivator 2. (155 aa)    
Predicted Functional Partners:
dcp1a
Decapping mRNA 1A.
    
 0.962
smg8
SMG8 nonsense mediated mRNA decay factor.
     
 0.845
smg5
SMG5 nonsense mediated mRNA decay factor.
     
 0.841
LOC105417758
Decapping mRNA 1B.
    
 0.838
smg9
SMG9 nonsense mediated mRNA decay factor.
     
 0.815
LOC101064659
Uncharacterized protein.
    
 0.785
UPF1
Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).
    
 0.785
smg6
SMG6 nonsense mediated mRNA decay factor.
     
 0.739
Dcp2
DCP2 domain-containing protein.
    
 
 0.683
eif4a3
Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family.
     
 0.636
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
Server load: low (30%) [HD]