ENSTRUP00000049862 protein (Takifugu rubripes)

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Known Interactions

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Predicted Interactions

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ENSTRUP00000049862

Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (65 aa)

Predicted Functional Partners:

gna12

0.939

BDKRB2

0.915

LOC101075438

0.915

LOC105418661

0.913

pak1

0.913

pak4

0.913

pak5

0.913

PAK3

0.913

pak2

0.913

LOC101076479

0.913

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDKRB2	ENSTRUP00000049862	ENSTRUP00000034471	ENSTRUP00000049862	Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.915
BDKRB2	LOC101075438	ENSTRUP00000034471	ENSTRUP00000034572	Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family.	Bradykinin receptor B1; Belongs to the G-protein coupled receptor 1 family.	0.917
ENSTRUP00000049862	BDKRB2	ENSTRUP00000049862	ENSTRUP00000034471	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family.	0.915
ENSTRUP00000049862	LOC101075438	ENSTRUP00000049862	ENSTRUP00000034572	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Bradykinin receptor B1; Belongs to the G-protein coupled receptor 1 family.	0.915
ENSTRUP00000049862	LOC101076479	ENSTRUP00000049862	ENSTRUP00000064836	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Non-specific serine/threonine protein kinase.	0.913
ENSTRUP00000049862	LOC105418661	ENSTRUP00000049862	ENSTRUP00000010568	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Non-specific serine/threonine protein kinase.	0.913
ENSTRUP00000049862	PAK3	ENSTRUP00000049862	ENSTRUP00000042993	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Non-specific serine/threonine protein kinase.	0.913
ENSTRUP00000049862	gna12	ENSTRUP00000049862	ENSTRUP00000029080	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	G protein subunit alpha 12.	0.939
ENSTRUP00000049862	pak1	ENSTRUP00000049862	ENSTRUP00000011910	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Non-specific serine/threonine protein kinase.	0.913
ENSTRUP00000049862	pak2	ENSTRUP00000049862	ENSTRUP00000063452	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Non-specific serine/threonine protein kinase.	0.913
ENSTRUP00000049862	pak4	ENSTRUP00000049862	ENSTRUP00000020813	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Non-specific serine/threonine protein kinase.	0.913
ENSTRUP00000049862	pak5	ENSTRUP00000049862	ENSTRUP00000024551	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Non-specific serine/threonine protein kinase.	0.913
LOC101075438	BDKRB2	ENSTRUP00000034572	ENSTRUP00000034471	Bradykinin receptor B1; Belongs to the G-protein coupled receptor 1 family.	Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family.	0.917
LOC101075438	ENSTRUP00000049862	ENSTRUP00000034572	ENSTRUP00000049862	Bradykinin receptor B1; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.915
LOC101076479	ENSTRUP00000049862	ENSTRUP00000064836	ENSTRUP00000049862	Non-specific serine/threonine protein kinase.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.913
LOC101076479	PAK3	ENSTRUP00000064836	ENSTRUP00000042993	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.404
LOC101076479	pak1	ENSTRUP00000064836	ENSTRUP00000011910	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.404
LOC101076479	pak2	ENSTRUP00000064836	ENSTRUP00000063452	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.405
LOC105418661	ENSTRUP00000049862	ENSTRUP00000010568	ENSTRUP00000049862	Non-specific serine/threonine protein kinase.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.913
LOC105418661	PAK3	ENSTRUP00000010568	ENSTRUP00000042993	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.409

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.82

expected number of edges:

27

PPI enrichment p-value:

0.542

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043328

Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

7 of 16

2.87

7.47

6.01e-15

GO:0036258

Multivesicular body assembly

7 of 22

2.74

7.07

1.91e-14

GO:0090148

Membrane fission

7 of 33

2.56

6.55

7.59e-14

GO:0007034

Vacuolar transport

8 of 154

1.95

4.47

4.20e-12

GO:0046755

Viral budding

5 of 28

2.48

4.26

4.88e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043130

Ubiquitin binding

5 of 102

1.92

2.37

8.10e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0036452

ESCRT complex

8 of 27

2.7

8.45

1.68e-17

GO:0000813

ESCRT I complex

6 of 13

2.9

6.77

1.71e-13

GO:0031902

Late endosome membrane

7 of 151

1.9

3.76

4.65e-10

GO:0010008

Endosome membrane

8 of 498

1.44

2.25

1.62e-08

GO:0070062

Extracellular exosome

8 of 1471

0.97

3.57e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21610

Endosomal Sorting Complex Required For Transport (ESCRT), and USP8 dimerisation domain

10 of 58

2.47

9.16

8.39e-21

CL:21613

Endosomal Sorting Complex Required For Transport (ESCRT)

9 of 43

2.55

8.75

4.99e-19

CL:21665

Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

6 of 14

2.87

6.56

3.89e-13

CL:21667

ESCRT I complex

3 of 6

2.93

2.68

1.26e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04144

Endocytosis

7 of 439

1.44

2.01

4.25e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-917729

Endosomal Sorting Complex Required For Transport (ESCRT)

9 of 49

2.5

8.42

1.23e-18

MAP-9706019

RHOBTB3 ATPase cycle

3 of 14

2.56

2.39

3.47e-05

MAP-9612973

Autophagy

5 of 203

1.62

1.87

2.97e-05

MAP-199991

Membrane Trafficking

9 of 842

1.26

1.78

3.31e-08

MAP-5653656

Vesicle-mediated transport

9 of 942

1.21

1.65

5.97e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0036452

ESCRT complex

7 of 35

2.53

6.44

1.08e-13

GOCC:0000813

ESCRT I complex

5 of 11

2.89

5.35

1.03e-10

GOCC:0010008

Endosome membrane

7 of 221

1.73

3.04

7.44e-09

GOCC:0098796

Membrane protein complex

6 of 1181

0.94

0.7

0.0044

GOCC:0031090

Organelle membrane

8 of 2027

0.83

0.69

0.00071

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0967

Endosome

5 of 95

1.95

2.8

7.42e-07

KW-0653

Protein transport

6 of 281

1.56

2.17

1.11e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10240

Multivesicular body subunit 12

2 of 2

3.23

1.31

0.0043

PF07200

Modifier of rudimentary (Mod(r)) protein

2 of 4

2.93

1.25

0.0054

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00064

Protein present in Fab1, YOTB, Vac1, and EEA1

3 of 25

2.31

1.8

0.00040

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