LOC101076881 protein (Takifugu rubripes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

LOC101076881

Uncharacterized protein. (343 aa)

Predicted Functional Partners:

ilf2

0.542

taf6l

0.499

runx3

0.476

runx2

0.476

runx1

0.476

snrpd2

0.475

ALYREF

0.466

hnrnpm

0.455

hnrnpk

0.454

LOC101076991

0.454

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALYREF	LOC101076881	ENSTRUP00000022188	ENSTRUP00000051263	Aly/REF export factor.	Uncharacterized protein.	0.466
ALYREF	LOC101076991	ENSTRUP00000022188	ENSTRUP00000080335	Aly/REF export factor.	Heterogeneous nuclear ribonucleoprotein K, like.	0.548
ALYREF	hnrnpk	ENSTRUP00000022188	ENSTRUP00000063053	Aly/REF export factor.	Heterogeneous nuclear ribonucleoprotein K.	0.548
ALYREF	hnrnpm	ENSTRUP00000022188	ENSTRUP00000069160	Aly/REF export factor.	Heterogeneous nuclear ribonucleoprotein M.	0.729
ALYREF	ilf2	ENSTRUP00000022188	ENSTRUP00000076446	Aly/REF export factor.	Interleukin enhancer binding factor 2.	0.753
ALYREF	snrpd2	ENSTRUP00000022188	ENSTRUP00000071624	Aly/REF export factor.	Small nuclear ribonucleoprotein Sm D2.	0.531
LOC101076881	ALYREF	ENSTRUP00000051263	ENSTRUP00000022188	Uncharacterized protein.	Aly/REF export factor.	0.466
LOC101076881	LOC101076991	ENSTRUP00000051263	ENSTRUP00000080335	Uncharacterized protein.	Heterogeneous nuclear ribonucleoprotein K, like.	0.454
LOC101076881	hnrnpk	ENSTRUP00000051263	ENSTRUP00000063053	Uncharacterized protein.	Heterogeneous nuclear ribonucleoprotein K.	0.454
LOC101076881	hnrnpm	ENSTRUP00000051263	ENSTRUP00000069160	Uncharacterized protein.	Heterogeneous nuclear ribonucleoprotein M.	0.455
LOC101076881	ilf2	ENSTRUP00000051263	ENSTRUP00000076446	Uncharacterized protein.	Interleukin enhancer binding factor 2.	0.542
LOC101076881	runx1	ENSTRUP00000051263	ENSTRUP00000063706	Uncharacterized protein.	Runt-related transcription factor.	0.476
LOC101076881	runx2	ENSTRUP00000051263	ENSTRUP00000008221	Uncharacterized protein.	Runt-related transcription factor.	0.476
LOC101076881	runx3	ENSTRUP00000051263	ENSTRUP00000003495	Uncharacterized protein.	Runt-related transcription factor.	0.476
LOC101076881	snrpd2	ENSTRUP00000051263	ENSTRUP00000071624	Uncharacterized protein.	Small nuclear ribonucleoprotein Sm D2.	0.475
LOC101076881	taf6l	ENSTRUP00000051263	ENSTRUP00000032187	Uncharacterized protein.	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor.	0.499
LOC101076991	ALYREF	ENSTRUP00000080335	ENSTRUP00000022188	Heterogeneous nuclear ribonucleoprotein K, like.	Aly/REF export factor.	0.548
LOC101076991	LOC101076881	ENSTRUP00000080335	ENSTRUP00000051263	Heterogeneous nuclear ribonucleoprotein K, like.	Uncharacterized protein.	0.454
LOC101076991	hnrnpm	ENSTRUP00000080335	ENSTRUP00000069160	Heterogeneous nuclear ribonucleoprotein K, like.	Heterogeneous nuclear ribonucleoprotein M.	0.983
LOC101076991	ilf2	ENSTRUP00000080335	ENSTRUP00000076446	Heterogeneous nuclear ribonucleoprotein K, like.	Interleukin enhancer binding factor 2.	0.551

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

42

average node degree:

7.64

avg. local clustering coefficient:

0.671

expected number of edges:

13

PPI enrichment p-value:

2.58e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030433

Ubiquitin-dependent ERAD pathway

7 of 79

2.18

4.55

1.30e-10

GO:0006620

Post-translational protein targeting to endoplasmic reticulum membrane

4 of 15

2.66

3.5

2.71e-07

GO:0030970

Retrograde protein transport, ER to cytosol

4 of 20

2.53

3.3

5.49e-07

GO:0006886

Intracellular protein transport

9 of 676

1.36

2.03

2.26e-08

GO:0006511

Ubiquitin-dependent protein catabolic process

8 of 554

1.39

1.99

1.62e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0048408

Epidermal growth factor binding

4 of 6

3.06

4.02

4.41e-08

GO:0043022

Ribosome binding

5 of 81

2.02

2.77

1.33e-06

GO:0060090

Molecular adaptor activity

4 of 405

1.23

0.65

0.0306

GO:0044877

Protein-containing complex binding

6 of 1270

0.91

0.57

0.0183

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071256

Translocon complex

5 of 5

3.23

6.01

1.00e-11

GO:0031205

Endoplasmic reticulum Sec complex

4 of 4

3.23

4.63

3.74e-09

GO:0005784

Sec61 translocon complex

4 of 4

3.23

4.63

3.74e-09

GO:0044322

Endoplasmic reticulum quality control compartment

4 of 18

2.58

3.59

1.56e-07

GO:0072380

TRC complex

3 of 4

3.11

3.24

1.26e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18881

Oligosaccharyltransferase complex, and Translocon complex

5 of 30

2.45

3.86

3.05e-08

CL:11533

ER membrane insertion complex, and GET complex

3 of 12

2.63

2.35

4.53e-05

CL:18929

Post-translational protein targeting to membrane, translocation, and SecY

2 of 5

2.84

1.34

0.0038

CL:18883

Oligosaccharyltransferase complex, and Translocon-associated protein beta (TRAPB)

2 of 22

2.19

0.74

0.0430

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03060

Protein export

5 of 43

2.3

3.88

1.39e-08

map04145

Phagosome

5 of 236

1.56

1.81

2.50e-05

map04141

Protein processing in endoplasmic reticulum

5 of 336

1.41

1.48

9.33e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9609523

Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

11 of 35

2.73

12.55

8.76e-27

MAP-9609507

Protein localization

11 of 235

1.9

5.76

1.31e-18

MAP-1236974

ER-Phagosome pathway

5 of 119

1.86

2.46

2.95e-06

MAP-1236975

Antigen processing-Cross presentation

5 of 138

1.79

2.33

4.53e-06

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

5 of 356

1.38

1.3

0.00037

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0071256

Translocon complex

5 of 13

2.82

5.01

4.05e-10

GOCC:0005784

Sec61 translocon complex

4 of 12

2.76

3.81

7.71e-08

GOCC:0072380

TRC complex

2 of 2

3.23

1.81

0.00054

GOCC:0005789

Endoplasmic reticulum membrane

6 of 460

1.35

1.5

3.75e-05

GOCC:0005783

Endoplasmic reticulum

6 of 935

1.04

0.86

0.0014

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

5 of 44

2.29

3.81

1.90e-08

KW-0256

Endoplasmic reticulum

5 of 163

1.72

2.22

5.08e-06

KW-0802

TPR repeat

4 of 126

1.73

1.84

7.43e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03911

Sec61beta family

3 of 3

3.23

2.85

6.92e-06

PF16546

Homodimerisation domain of SGTA

2 of 2

3.23

1.48

0.0022

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00028

Tetratricopeptide repeats

3 of 93

1.74

0.89

0.0169

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