LOC101065469 protein (Takifugu rubripes) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

LOC101065469

Forkhead box E3. (417 aa)

Predicted Functional Partners:

tipin

0.596

plk3

0.535

H2T6G5_TAKRU

0.516

LOC101071401

0.506

SPDEF

0.506

calm2-2

0.489

fzd8

0.468

hnrnpk

0.467

H2UXB1_TAKRU

0.459

cdc25b

0.457

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2T6G5_TAKRU	LOC101065469	ENSTRUP00000067341	ENSTRUP00000052183	PHD-type domain-containing protein.	Forkhead box E3.	0.516
H2T6G5_TAKRU	LOC101071401	ENSTRUP00000067341	ENSTRUP00000003294	PHD-type domain-containing protein.	SAM pointed domain containing ETS transcription factor.	0.426
H2T6G5_TAKRU	SPDEF	ENSTRUP00000067341	ENSTRUP00000027896	PHD-type domain-containing protein.	SAM pointed domain containing ETS transcription factor.	0.426
H2T6G5_TAKRU	calm2-2	ENSTRUP00000067341	ENSTRUP00000057178	PHD-type domain-containing protein.	Calmodulin 3.	0.446
H2T6G5_TAKRU	tipin	ENSTRUP00000067341	ENSTRUP00000050212	PHD-type domain-containing protein.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.523
H2UXB1_TAKRU	LOC101065469	ENSTRUP00000041590	ENSTRUP00000052183	COesterase domain-containing protein.	Forkhead box E3.	0.459
LOC101065469	H2T6G5_TAKRU	ENSTRUP00000052183	ENSTRUP00000067341	Forkhead box E3.	PHD-type domain-containing protein.	0.516
LOC101065469	H2UXB1_TAKRU	ENSTRUP00000052183	ENSTRUP00000041590	Forkhead box E3.	COesterase domain-containing protein.	0.459
LOC101065469	LOC101071401	ENSTRUP00000052183	ENSTRUP00000003294	Forkhead box E3.	SAM pointed domain containing ETS transcription factor.	0.506
LOC101065469	SPDEF	ENSTRUP00000052183	ENSTRUP00000027896	Forkhead box E3.	SAM pointed domain containing ETS transcription factor.	0.506
LOC101065469	calm2-2	ENSTRUP00000052183	ENSTRUP00000057178	Forkhead box E3.	Calmodulin 3.	0.489
LOC101065469	cdc25b	ENSTRUP00000052183	ENSTRUP00000086013	Forkhead box E3.	Cell division cycle 25B.	0.457
LOC101065469	fzd8	ENSTRUP00000052183	ENSTRUP00000048893	Forkhead box E3.	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family.	0.468
LOC101065469	hnrnpk	ENSTRUP00000052183	ENSTRUP00000063053	Forkhead box E3.	Heterogeneous nuclear ribonucleoprotein K.	0.467
LOC101065469	plk3	ENSTRUP00000052183	ENSTRUP00000003764	Forkhead box E3.	Serine/threonine-protein kinase PLK.	0.535
LOC101065469	tipin	ENSTRUP00000052183	ENSTRUP00000050212	Forkhead box E3.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.596
LOC101071401	H2T6G5_TAKRU	ENSTRUP00000003294	ENSTRUP00000067341	SAM pointed domain containing ETS transcription factor.	PHD-type domain-containing protein.	0.426
LOC101071401	LOC101065469	ENSTRUP00000003294	ENSTRUP00000052183	SAM pointed domain containing ETS transcription factor.	Forkhead box E3.	0.506
LOC101071401	calm2-2	ENSTRUP00000003294	ENSTRUP00000057178	SAM pointed domain containing ETS transcription factor.	Calmodulin 3.	0.450
LOC101071401	fzd8	ENSTRUP00000003294	ENSTRUP00000048893	SAM pointed domain containing ETS transcription factor.	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family.	0.405

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

48

average node degree:

8.73

avg. local clustering coefficient:

0.867

expected number of edges:

13

PPI enrichment p-value:

7.77e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050853

B cell receptor signaling pathway

4 of 17

2.65

3.3

6.51e-07

GO:0043687

Post-translational protein modification

4 of 28

2.44

2.94

2.34e-06

GO:0035162

Embryonic hemopoiesis

4 of 36

2.33

2.74

4.95e-06

GO:0042113

B cell activation

4 of 71

2.03

2.16

4.12e-05

GO:0007596

Blood coagulation

4 of 74

2.01

2.15

4.17e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035403

Histone kinase activity (H3-T6 specific)

4 of 4

3.28

4.47

7.57e-09

GO:0050681

Nuclear androgen receptor binding

4 of 16

2.68

3.61

1.74e-07

GO:0004698

Calcium-dependent protein kinase C activity

4 of 23

2.52

3.37

3.78e-07

GO:0030374

Nuclear receptor coactivator activity

4 of 42

2.26

2.89

1.94e-06

GO:0015279

Store-operated calcium channel activity

2 of 12

2.5

1.34

0.0035

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005923

Bicellular tight junction

3 of 110

1.72

0.77

0.0304

GO:0016324

Apical plasma membrane

3 of 190

1.48

0.69

0.0374

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8304

Mixed, incl. L27 domain, and PB1 domain

5 of 27

2.55

4.12

1.18e-08

CL:34179

Transient receptor ion channel II, and Protein kinase C, alpha/beta/gamma types

3 of 5

3.06

2.85

6.52e-06

CL:8307

Tight junction interactions, and Transmembrane protein 237

3 of 21

2.44

2.07

0.00013

CL:8337

L27 domain

2 of 6

2.8

1.45

0.0023

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04370

VEGF signaling pathway

4 of 89

1.93

2.2

2.26e-05

map04012

ErbB signaling pathway

4 of 128

1.78

1.95

4.63e-05

map04912

GnRH signaling pathway

4 of 140

1.74

1.92

4.63e-05

map04540

Gap junction

4 of 144

1.72

1.91

4.63e-05

map04916

Melanogenesis

4 of 148

1.71

1.9

4.63e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-114516

Disinhibition of SNARE formation

4 of 7

3.04

4.17

2.23e-08

MAP-5099900

WNT5A-dependent internalization of FZD4

4 of 14

2.74

3.74

1.03e-07

MAP-416993

Trafficking of GluR2-containing AMPA receptors

4 of 27

2.45

3.21

7.04e-07

MAP-399721

Glutamate binding, activation of AMPA receptors and synaptic plasticity

4 of 30

2.41

3.16

7.78e-07

MAP-399719

Trafficking of AMPA receptors

4 of 30

2.41

3.16

7.78e-07

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 12264

0.23

0.22

0.0243

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016324

Apical plasma membrane

3 of 53

2.03

1.23

0.0044

GOCC:0005923

Bicellular tight junction

3 of 58

1.99

1.22

0.0044

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0723

Serine/threonine-protein kinase

3 of 227

1.4

0.66

0.0395

KW-0863

Zinc-finger

5 of 1069

0.95

0.52

0.0395

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR014375

Protein kinase C, alpha/beta/gamma types

3 of 3

3.28

2.68

1.45e-05

IPR020454

Diacylglycerol/phorbol-ester binding

3 of 24

2.38

1.59

0.0011

IPR015132

L27-2

2 of 2

3.28

1.45

0.0025

IPR017892

Protein kinase, C-terminal

3 of 34

2.23

1.44

0.0019

IPR000961

AGC-kinase, C-terminal

3 of 65

1.94

1.18

0.0051

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00133

Extension to Ser/Thr-type protein kinases

4 of 69

2.04

2.2

3.39e-05

SM00109

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

4 of 82

1.97

2.16

3.39e-05

SM00228

Domain present in PSD-95, Dlg, and ZO-1/2.

5 of 208

1.66

1.89

3.39e-05

SM00239

Protein kinase C conserved region 2 (CalB)

4 of 178

1.63

1.53

0.00033

SM01420

Transient receptor ion channel II

2 of 8

2.68

1.52

0.0017

(more ...)

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