H2S9Q2_TAKRU protein (Takifugu rubripes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

H2S9Q2_TAKRU

Ig-like domain-containing protein. (164 aa)

Predicted Functional Partners:

ENSTRUP00000007034

0.449

ENSTRUP00000005926

0.434

ENSTRUP00000050368

0.428

LOC101069436

0.420

ENSTRUP00000085013

0.415

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSTRUP00000005926	H2S9Q2_TAKRU	ENSTRUP00000005926	ENSTRUP00000052251	annotation not available	Ig-like domain-containing protein.	0.434
ENSTRUP00000007034	H2S9Q2_TAKRU	ENSTRUP00000007034	ENSTRUP00000052251	annotation not available	Ig-like domain-containing protein.	0.449
ENSTRUP00000050368	H2S9Q2_TAKRU	ENSTRUP00000050368	ENSTRUP00000052251	annotation not available	Ig-like domain-containing protein.	0.428
ENSTRUP00000085013	H2S9Q2_TAKRU	ENSTRUP00000085013	ENSTRUP00000052251	annotation not available	Ig-like domain-containing protein.	0.415
H2S9Q2_TAKRU	ENSTRUP00000005926	ENSTRUP00000052251	ENSTRUP00000005926	Ig-like domain-containing protein.	annotation not available	0.434
H2S9Q2_TAKRU	ENSTRUP00000007034	ENSTRUP00000052251	ENSTRUP00000007034	Ig-like domain-containing protein.	annotation not available	0.449
H2S9Q2_TAKRU	ENSTRUP00000050368	ENSTRUP00000052251	ENSTRUP00000050368	Ig-like domain-containing protein.	annotation not available	0.428
H2S9Q2_TAKRU	ENSTRUP00000085013	ENSTRUP00000052251	ENSTRUP00000085013	Ig-like domain-containing protein.	annotation not available	0.415
H2S9Q2_TAKRU	LOC101069436	ENSTRUP00000052251	ENSTRUP00000085477	Ig-like domain-containing protein.	MCL1 apoptosis regulator, BCL2 family member b.	0.420
LOC101069436	H2S9Q2_TAKRU	ENSTRUP00000085477	ENSTRUP00000052251	MCL1 apoptosis regulator, BCL2 family member b.	Ig-like domain-containing protein.	0.420

Network Stats

number of nodes:

4

number of edges:

6

average node degree:

3

avg. local clustering coefficient:

1

expected number of edges:

4

PPI enrichment p-value:

0.136

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043484

Regulation of RNA splicing

6 of 152

1.85

2.6

1.17e-06

GO:0000398

mRNA splicing, via spliceosome

6 of 285

1.58

1.84

2.31e-05

GO:0050684

Regulation of mRNA processing

4 of 136

1.72

1.41

0.0010

GO:0048024

Regulation of mRNA splicing, via spliceosome

3 of 105

1.71

0.81

0.0252

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016604

Nuclear body

6 of 757

1.15

0.93

0.0020

GO:0016607

Nuclear speck

4 of 398

1.26

0.81

0.0109

GO:0005654

Nucleoplasm

9 of 3218

0.7

0.54

0.0025

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14339

Mixed, incl. SRSF7, RNA recognition motif, and Primary miRNA processing

6 of 13

2.92

6.49

6.46e-13

CL:14341

Mixed, incl. DNA topoisomerase binding, and SRSF7, RNA recognition motif

4 of 6

3.08

4.61

3.57e-09

CL:15958

Mixed, incl. THRAP3/BCLAF1 family, and Arginine/Serine-Rich protein 1

3 of 8

2.83

2.84

5.99e-06

CL:14353

Mixed, incl. SRSF7, RNA recognition motif, and Primary miRNA processing

2 of 6

2.78

1.5

0.0019

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

5 of 337

1.43

1.41

0.00022

map05168

Herpes simplex virus 1 infection

4 of 507

1.15

0.67

0.0221

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72163

mRNA Splicing - Major Pathway

5 of 380

1.37

1.1

0.0020

MAP-72172

mRNA Splicing

5 of 393

1.36

1.09

0.0020

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

5 of 519

1.24

0.95

0.0030

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016607

Nuclear speck

4 of 89

1.91

1.74

0.00027

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0694

RNA-binding

5 of 377

1.38

1.3

0.00038

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000504

RNA recognition motif domain

5 of 278

1.51

1.2

0.0018

IPR035979

RNA-binding domain superfamily

5 of 305

1.47

1.17

0.0018

IPR012677

Nucleotide-binding alpha-beta plait domain superfamily

5 of 320

1.45

1.16

0.0018

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00360

RNA recognition motif

5 of 271

1.52

0.00018

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