tmem141 protein (Takifugu rubripes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

tmem141

Transmembrane protein 141. (125 aa)

Predicted Functional Partners:

pusl1

0.826

tmem244

0.804

rsrc1

0.777

phpt1

0.576

LOC101067325

0.566

ganab

0.565

snap47

0.507

LOC101068144

0.435

EIF3F

0.405

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF3F	rsrc1	ENSTRUP00000084787	ENSTRUP00000036060	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Arginine/serine-rich coiled-coil 1.	0.897
EIF3F	tmem141	ENSTRUP00000084787	ENSTRUP00000057602	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Transmembrane protein 141.	0.405
LOC101067325	ganab	ENSTRUP00000061640	ENSTRUP00000078036	Uncharacterized protein.	Glucosidase, alpha; neutral AB; Belongs to the glycosyl hydrolase 31 family.	0.457
LOC101067325	tmem141	ENSTRUP00000061640	ENSTRUP00000057602	Uncharacterized protein.	Transmembrane protein 141.	0.566
LOC101068144	pusl1	ENSTRUP00000083007	ENSTRUP00000025446	Transmembrane protein 244-like isoform X1.	tRNA pseudouridine synthase.	0.426
LOC101068144	tmem141	ENSTRUP00000083007	ENSTRUP00000057602	Transmembrane protein 244-like isoform X1.	Transmembrane protein 141.	0.435
ganab	LOC101067325	ENSTRUP00000078036	ENSTRUP00000061640	Glucosidase, alpha; neutral AB; Belongs to the glycosyl hydrolase 31 family.	Uncharacterized protein.	0.457
ganab	tmem141	ENSTRUP00000078036	ENSTRUP00000057602	Glucosidase, alpha; neutral AB; Belongs to the glycosyl hydrolase 31 family.	Transmembrane protein 141.	0.565
phpt1	tmem141	ENSTRUP00000050670	ENSTRUP00000057602	Phosphohistidine phosphatase 1.	Transmembrane protein 141.	0.576
pusl1	LOC101068144	ENSTRUP00000025446	ENSTRUP00000083007	tRNA pseudouridine synthase.	Transmembrane protein 244-like isoform X1.	0.426
pusl1	rsrc1	ENSTRUP00000025446	ENSTRUP00000036060	tRNA pseudouridine synthase.	Arginine/serine-rich coiled-coil 1.	0.801
pusl1	snap47	ENSTRUP00000025446	ENSTRUP00000035998	tRNA pseudouridine synthase.	Synaptosome associated protein 47.	0.507
pusl1	tmem141	ENSTRUP00000025446	ENSTRUP00000057602	tRNA pseudouridine synthase.	Transmembrane protein 141.	0.826
pusl1	tmem244	ENSTRUP00000025446	ENSTRUP00000050862	tRNA pseudouridine synthase.	Transmembrane protein 244.	0.804
rsrc1	EIF3F	ENSTRUP00000036060	ENSTRUP00000084787	Arginine/serine-rich coiled-coil 1.	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.897
rsrc1	pusl1	ENSTRUP00000036060	ENSTRUP00000025446	Arginine/serine-rich coiled-coil 1.	tRNA pseudouridine synthase.	0.801
rsrc1	snap47	ENSTRUP00000036060	ENSTRUP00000035998	Arginine/serine-rich coiled-coil 1.	Synaptosome associated protein 47.	0.494
rsrc1	tmem141	ENSTRUP00000036060	ENSTRUP00000057602	Arginine/serine-rich coiled-coil 1.	Transmembrane protein 141.	0.777
rsrc1	tmem244	ENSTRUP00000036060	ENSTRUP00000050862	Arginine/serine-rich coiled-coil 1.	Transmembrane protein 244.	0.731
snap47	pusl1	ENSTRUP00000035998	ENSTRUP00000025446	Synaptosome associated protein 47.	tRNA pseudouridine synthase.	0.507

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.923

expected number of edges:

11

PPI enrichment p-value:

0.071

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006265

DNA topological change

3 of 9

2.85

2.37

4.71e-05

GO:0000819

Sister chromatid segregation

5 of 113

1.97

2.35

1.14e-05

GO:0000712

Resolution of meiotic recombination intermediates

3 of 17

2.57

2.12

0.00012

GO:0048524

Positive regulation of viral process

3 of 25

2.4

1.96

0.00021

GO:0045069

Regulation of viral genome replication

3 of 26

2.39

1.96

0.00021

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003918

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

3 of 5

3.1

2.71

1.19e-05

GO:0005080

Protein kinase C binding

3 of 32

2.3

1.77

0.00046

GO:0031208

POZ domain binding

2 of 3

3.15

1.58

0.0014

GO:0042826

Histone deacetylase binding

3 of 57

2.05

1.47

0.0014

GO:0030332

Cyclin binding

2 of 14

2.48

1.12

0.0087

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005827

Polar microtubule

2 of 5

2.93

1.25

0.0054

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:35892871

(2022) High-Throughput CRISPR Screening in Hematological Neoplasms.

3 of 117

1.73

1.04

0.0079

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2630

Mixed, incl. Protein sumoylation, and DNA topological change

4 of 38

2.35

2.51

1.53e-05

CL:8237

Stem cell division, and SPOP, C-terminal BACK domain

2 of 5

2.93

1.19

0.0072

CL:2689

DNA topological change, and tyrosyl-DNA phosphodiesterase activity

2 of 7

2.78

1.12

0.0093

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

sdu04120

Ubiquitin mediated proteolysis

3 of 150

1.63

1.02

0.0074

sdu04340

Hedgehog signaling pathway

2 of 58

1.86

0.8

0.0294

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-4615885

SUMOylation of DNA replication proteins

3 of 56

2.05

1.24

0.0042

MAP-9706019

RHOBTB3 ATPase cycle

2 of 19

2.35

0.95

0.0177

MAP-983168

Antigen processing: Ubiquitination & Proteasome degradation

5 of 569

1.27

0.93

0.0042

MAP-983169

Class I MHC mediated antigen processing & presentation

5 of 655

1.21

0.89

0.0042

MAP-9013418

RHOBTB2 GTPase cycle

2 of 31

2.13

0.78

0.0355

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009330

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex

3 of 3

3.32

3.11

2.44e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001241

DNA topoisomerase, type IIA

3 of 3

3.32

2.73

1.18e-05

IPR013760

DNA topoisomerase, type IIA-like domain superfamily

2 of 2

3.32

1.3

0.0046

IPR013758

DNA topoisomerase, type IIA, domain A, alpha-beta

2 of 2

3.32

1.3

0.0046

IPR013757

DNA topoisomerase, type IIA, alpha-helical domain superfamily

2 of 2

3.32

1.3

0.0046

IPR002205

DNA topoisomerase, type IIA, domain A

2 of 2

3.32

1.3

0.0046

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00434

DNA Topoisomerase IV

2 of 2

3.32

1.67

0.00097

SM00433

TopoisomeraseII

2 of 2

3.32

1.67

0.00097

SM00884

Cullin protein neddylation domain

2 of 9

2.67

1.38

0.0030

SM00182

Cullin

2 of 9

2.67

1.38

0.0030

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