nr2c2 protein (Takifugu rubripes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

nr2c2

Nuclear receptor subfamily 2, group C, member 2. (629 aa)

Predicted Functional Partners:

LOC101077966

0.634

LOC101068454

0.634

ncor2

0.633

ncor1

0.633

JAZF1

0.585

LOC101064920

0.585

trip11

0.557

ENSTRUP00000077588

0.557

trip13

0.543

HDAC3

0.535

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSTRUP00000077588	HDAC3	ENSTRUP00000077588	ENSTRUP00000015206	NRIP1_repr_2 domain-containing protein.	Histone deacetylase 3.	0.411
ENSTRUP00000077588	nr2c2	ENSTRUP00000077588	ENSTRUP00000067518	NRIP1_repr_2 domain-containing protein.	Nuclear receptor subfamily 2, group C, member 2.	0.557
HDAC3	ENSTRUP00000077588	ENSTRUP00000015206	ENSTRUP00000077588	Histone deacetylase 3.	NRIP1_repr_2 domain-containing protein.	0.411
HDAC3	ncor1	ENSTRUP00000015206	ENSTRUP00000076945	Histone deacetylase 3.	Nuclear receptor corepressor 1.	0.959
HDAC3	ncor2	ENSTRUP00000015206	ENSTRUP00000030818	Histone deacetylase 3.	Nuclear receptor corepressor 2.	0.940
HDAC3	nr2c2	ENSTRUP00000015206	ENSTRUP00000067518	Histone deacetylase 3.	Nuclear receptor subfamily 2, group C, member 2.	0.535
JAZF1	nr2c2	ENSTRUP00000046631	ENSTRUP00000067518	Juxtaposed with another zinc finger protein 1.	Nuclear receptor subfamily 2, group C, member 2.	0.585
LOC101064920	nr2c2	ENSTRUP00000083622	ENSTRUP00000067518	Juxtaposed with another zinc finger protein 1.	Nuclear receptor subfamily 2, group C, member 2.	0.585
LOC101068454	ncor1	ENSTRUP00000087379	ENSTRUP00000076945	Uncharacterized protein.	Nuclear receptor corepressor 1.	0.521
LOC101068454	ncor2	ENSTRUP00000087379	ENSTRUP00000030818	Uncharacterized protein.	Nuclear receptor corepressor 2.	0.494
LOC101068454	nr2c2	ENSTRUP00000087379	ENSTRUP00000067518	Uncharacterized protein.	Nuclear receptor subfamily 2, group C, member 2.	0.634
LOC101068454	trip11	ENSTRUP00000087379	ENSTRUP00000064855	Uncharacterized protein.	Thyroid hormone receptor interactor 11.	0.555
LOC101068454	trip13	ENSTRUP00000087379	ENSTRUP00000036592	Uncharacterized protein.	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family.	0.490
LOC101077966	ncor1	ENSTRUP00000023904	ENSTRUP00000076945	Nuclear receptor coactivator 3.	Nuclear receptor corepressor 1.	0.521
LOC101077966	ncor2	ENSTRUP00000023904	ENSTRUP00000030818	Nuclear receptor coactivator 3.	Nuclear receptor corepressor 2.	0.494
LOC101077966	nr2c2	ENSTRUP00000023904	ENSTRUP00000067518	Nuclear receptor coactivator 3.	Nuclear receptor subfamily 2, group C, member 2.	0.634
LOC101077966	trip11	ENSTRUP00000023904	ENSTRUP00000064855	Nuclear receptor coactivator 3.	Thyroid hormone receptor interactor 11.	0.598
LOC101077966	trip13	ENSTRUP00000023904	ENSTRUP00000036592	Nuclear receptor coactivator 3.	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family.	0.545
ncor1	HDAC3	ENSTRUP00000076945	ENSTRUP00000015206	Nuclear receptor corepressor 1.	Histone deacetylase 3.	0.959
ncor1	LOC101068454	ENSTRUP00000076945	ENSTRUP00000087379	Nuclear receptor corepressor 1.	Uncharacterized protein.	0.521

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.595

expected number of edges:

12

PPI enrichment p-value:

7.32e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1901678

Iron coordination entity transport

3 of 14

1.87

0.93

0.0162

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022857

Transmembrane transporter activity

7 of 387

0.8

0.5

0.0205

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030312

External encapsulating structure

5 of 71

1.39

0.00017

GO:0009279

Cell outer membrane

4 of 44

1.5

1.37

0.00051

GO:0031224

Intrinsic component of membrane

9 of 789

0.59

0.48

0.0010

GO:0071944

Cell periphery

8 of 726

0.58

0.44

0.0037

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5000

Protein transport, and TonB-dependent Receptor Plug Domain

6 of 31

1.82

2.8

2.13e-07

CL:5002

Mixed, incl. Biopolymer transport protein ExbD/TolR, and Transmembrane beta strand

5 of 19

1.96

2.75

1.03e-06

CL:5003

Biopolymer transport protein ExbD/TolR, and MotA/TolQ/ExbB proton channel

3 of 13

1.9

1.43

0.0014

CL:5028

Transmembrane beta strand

2 of 6

2.06

0.85

0.0260

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030312

External encapsulating structure

5 of 57

1.48

1.54

0.00012

GOCC:0009279

Cell outer membrane

3 of 40

1.41

0.71

0.0301

GOCC:0071944

Cell periphery

7 of 554

0.64

0.4

0.0301

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0798

TonB box

3 of 10

2.01

1.51

0.0011

KW-0675

Receptor

3 of 14

1.87

1.43

0.0013

KW-0998

Cell outer membrane

3 of 18

1.76

1.33

0.0017

KW-1134

Transmembrane beta strand

2 of 8

1.94

0.9

0.0190

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07715

TonB-dependent Receptor Plug Domain

4 of 11

2.1

2.26

2.93e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039426

TonB-dependent receptor-like

4 of 10

2.14

2.16

5.60e-05

IPR037066

TonB-dependent receptor, plug domain superfamily

4 of 11

2.1

2.14

5.60e-05

IPR012910

TonB-dependent receptor, plug domain

4 of 11

2.1

2.14

5.60e-05

IPR036942

TonB-dependent receptor-like, beta-barrel domain superfamily

3 of 10

2.01

1.4

0.0019

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (20%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About