LOC101074759 protein (Takifugu rubripes) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:

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[Homology]

Score

LOC101074759

Alpha-L-fucosidase 2. (554 aa)

Predicted Functional Partners:

snx9

0.663

slc22a23

0.649

LOC101078519

0.640

LOC101061169

0.602

glb1

0.601

coasy

0.570

ak2

0.566

hivep2

0.564

slc22a31

0.536

glb1l2

0.526

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101061169	LOC101074759	ENSTRUP00000023265	ENSTRUP00000082990	Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family.	Alpha-L-fucosidase 2.	0.602
LOC101074759	LOC101061169	ENSTRUP00000082990	ENSTRUP00000023265	Alpha-L-fucosidase 2.	Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family.	0.602
LOC101074759	LOC101078519	ENSTRUP00000082990	ENSTRUP00000017626	Alpha-L-fucosidase 2.	Taxilin beta b.	0.640
LOC101074759	ak2	ENSTRUP00000082990	ENSTRUP00000071070	Alpha-L-fucosidase 2.	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	0.566
LOC101074759	coasy	ENSTRUP00000082990	ENSTRUP00000080971	Alpha-L-fucosidase 2.	CoA synthase.	0.570
LOC101074759	glb1	ENSTRUP00000082990	ENSTRUP00000044943	Alpha-L-fucosidase 2.	Beta-galactosidase.	0.601
LOC101074759	glb1l2	ENSTRUP00000082990	ENSTRUP00000005571	Alpha-L-fucosidase 2.	Beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) b.	0.526
LOC101074759	hivep2	ENSTRUP00000082990	ENSTRUP00000040615	Alpha-L-fucosidase 2.	Human immunodeficiency virus type I enhancer binding protein 2a.	0.564
LOC101074759	slc22a23	ENSTRUP00000082990	ENSTRUP00000009685	Alpha-L-fucosidase 2.	Uncharacterized protein.	0.649
LOC101074759	slc22a31	ENSTRUP00000082990	ENSTRUP00000044212	Alpha-L-fucosidase 2.	Solute carrier family 22 member 31.	0.536
LOC101074759	snx9	ENSTRUP00000082990	ENSTRUP00000064478	Alpha-L-fucosidase 2.	Sorting nexin.	0.663
LOC101078519	LOC101074759	ENSTRUP00000017626	ENSTRUP00000082990	Taxilin beta b.	Alpha-L-fucosidase 2.	0.640
LOC101078519	hivep2	ENSTRUP00000017626	ENSTRUP00000040615	Taxilin beta b.	Human immunodeficiency virus type I enhancer binding protein 2a.	0.591
LOC101078519	slc22a23	ENSTRUP00000017626	ENSTRUP00000009685	Taxilin beta b.	Uncharacterized protein.	0.649
LOC101078519	slc22a31	ENSTRUP00000017626	ENSTRUP00000044212	Taxilin beta b.	Solute carrier family 22 member 31.	0.450
LOC101078519	snx9	ENSTRUP00000017626	ENSTRUP00000064478	Taxilin beta b.	Sorting nexin.	0.534
ak2	LOC101074759	ENSTRUP00000071070	ENSTRUP00000082990	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	Alpha-L-fucosidase 2.	0.566
ak2	coasy	ENSTRUP00000071070	ENSTRUP00000080971	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	CoA synthase.	0.408
coasy	LOC101074759	ENSTRUP00000080971	ENSTRUP00000082990	CoA synthase.	Alpha-L-fucosidase 2.	0.570
coasy	ak2	ENSTRUP00000080971	ENSTRUP00000071070	CoA synthase.	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	0.408

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

14

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 103

1.39

2.4

8.86e-11

GO:0044238

Primary metabolic process

11 of 1033

0.43

0.36

0.0011

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

9 of 53

1.63

3.29

2.17e-11

GO:0070180

Large ribosomal subunit rRNA binding

2 of 2

2.4

1.09

0.0098

GO:0019843

rRNA binding

4 of 40

1.4

1.07

0.0029

GO:0003723

RNA binding

5 of 89

1.15

0.89

0.0029

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

9 of 56

1.61

3.29

6.22e-12

GO:0044391

Ribosomal subunit

5 of 14

1.96

3.18

6.49e-08

GO:0015934

Large ribosomal subunit

3 of 8

1.98

1.97

9.75e-05

GO:0015935

Small ribosomal subunit

2 of 6

1.93

1.24

0.0038

GO:0005622

Intracellular anatomical structure

11 of 972

0.46

0.4

0.00011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:103

Ribosomal protein

10 of 65

1.59

3.36

7.11e-13

CL:107

Ribosomal protein

9 of 58

1.6

3.22

8.40e-12

CL:110

Ribosomal protein

8 of 51

1.6

3.01

2.01e-10

CL:112

Ribosomal protein

7 of 45

1.6

2.71

7.76e-09

CL:155

Structural constituent of ribosome

4 of 16

1.8

2.07

2.61e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

9 of 55

1.62

3.32

6.37e-12

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

7 of 40

1.65

2.76

1.68e-08

GOCC:0044391

Ribosomal subunit

4 of 16

1.8

2.09

2.30e-05

GOCC:0015935

Small ribosomal subunit

3 of 9

1.93

1.74

0.00028

GOCC:0043229

Intracellular organelle

10 of 270

0.97

1.14

9.78e-08

GOCC:0022627

Cytosolic small ribosomal subunit

2 of 7

1.86

1.0

0.0114

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

9 of 54

1.63

3.33

8.02e-12

KW-0699

rRNA-binding

4 of 38

1.43

1.25

0.00083

KW-0810

Translation regulation

2 of 5

2.01

1.03

0.0108

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