Casp8ap2 protein (Takifugu rubripes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

Casp8ap2

Uncharacterized protein. (1685 aa)

Predicted Functional Partners:

lsm11

0.566

LOC101079296

0.551

casp8

0.486

LOC101061322

0.486

ENSTRUP00000052105

0.482

sumo1

0.469

pias4

0.455

kctd2

0.453

ube2i

0.450

LOC101072687

0.450

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Casp8ap2	ENSTRUP00000052105	ENSTRUP00000085430	ENSTRUP00000052105	Uncharacterized protein.	Transmembrane protein 130.	0.482
Casp8ap2	LOC101061322	ENSTRUP00000085430	ENSTRUP00000044669	Uncharacterized protein.	Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.486
Casp8ap2	LOC101072687	ENSTRUP00000085430	ENSTRUP00000053339	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.450
Casp8ap2	LOC101079296	ENSTRUP00000085430	ENSTRUP00000052798	Uncharacterized protein.	LisH domain-containing protein.	0.551
Casp8ap2	casp8	ENSTRUP00000085430	ENSTRUP00000024467	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.486
Casp8ap2	kctd2	ENSTRUP00000085430	ENSTRUP00000054607	Uncharacterized protein.	Potassium channel tetramerization domain containing 2.	0.453
Casp8ap2	lsm11	ENSTRUP00000085430	ENSTRUP00000024440	Uncharacterized protein.	LSM11, U7 small nuclear RNA associated.	0.566
Casp8ap2	pias4	ENSTRUP00000085430	ENSTRUP00000045824	Uncharacterized protein.	Protein inhibitor of activated STAT, 4a.	0.455
Casp8ap2	sumo1	ENSTRUP00000085430	ENSTRUP00000061419	Uncharacterized protein.	Small ubiquitin-related modifier.	0.469
Casp8ap2	ube2i	ENSTRUP00000085430	ENSTRUP00000040080	Uncharacterized protein.	Ubiquitin-conjugating enzyme E2Ia; Belongs to the ubiquitin-conjugating enzyme family.	0.450
ENSTRUP00000052105	Casp8ap2	ENSTRUP00000052105	ENSTRUP00000085430	Transmembrane protein 130.	Uncharacterized protein.	0.482
LOC101061322	Casp8ap2	ENSTRUP00000044669	ENSTRUP00000085430	Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.486
LOC101072687	Casp8ap2	ENSTRUP00000053339	ENSTRUP00000085430	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.450
LOC101072687	pias4	ENSTRUP00000053339	ENSTRUP00000045824	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Protein inhibitor of activated STAT, 4a.	0.876
LOC101072687	sumo1	ENSTRUP00000053339	ENSTRUP00000061419	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Small ubiquitin-related modifier.	0.997
LOC101072687	ube2i	ENSTRUP00000053339	ENSTRUP00000040080	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2Ia; Belongs to the ubiquitin-conjugating enzyme family.	0.900
LOC101079296	Casp8ap2	ENSTRUP00000052798	ENSTRUP00000085430	LisH domain-containing protein.	Uncharacterized protein.	0.551
LOC101079296	lsm11	ENSTRUP00000052798	ENSTRUP00000024440	LisH domain-containing protein.	LSM11, U7 small nuclear RNA associated.	0.565
casp8	Casp8ap2	ENSTRUP00000024467	ENSTRUP00000085430	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.486
kctd2	Casp8ap2	ENSTRUP00000054607	ENSTRUP00000085430	Potassium channel tetramerization domain containing 2.	Uncharacterized protein.	0.453

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Network Stats

number of nodes:

5

number of edges:

6

average node degree:

2.4

avg. local clustering coefficient:

0.8

expected number of edges:

4

PPI enrichment p-value:

0.214

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051045

Negative regulation of membrane protein ectodomain proteolysis

4 of 5

3.57

6.73

4.23e-10

GO:0009725

Response to hormone

4 of 416

1.65

1.82

0.00033

GO:0034097

Response to cytokine

4 of 431

1.63

1.8

0.00035

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008191

Metalloendopeptidase inhibitor activity

4 of 13

3.16

6.05

2.64e-09

GO:0002020

Protease binding

4 of 73

2.41

3.98

7.50e-07

GO:0008270

Zinc ion binding

4 of 778

1.38

1.25

0.0021

GO:0046872

Metal ion binding

5 of 4369

0.73

0.43

0.0489

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031012

Extracellular matrix

5 of 521

1.65

2.37

7.39e-06

GO:0005576

Extracellular region

5 of 2032

1.06

0.9

0.0022

GO:0005615

Extracellular space

4 of 1283

1.16

0.82

0.0142

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23867

Hemopexin-like repeats, and P domain

5 of 35

2.82

6.9

5.91e-11

CL:23868

Hemopexin-like repeats, and Protease inhibitor I35 (TIMP)

4 of 29

2.81

5.38

1.42e-08

CL:23874

Peptidoglycan binding-like, and Protease inhibitor I35 (TIMP)

3 of 15

2.97

3.92

2.83e-06

CL:23876

Peptidase M10A, cysteine switch, zinc binding site, and Tissue inhibitor of metalloproteinase, conserved site

2 of 10

2.97

2.04

0.0014

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1592389

Activation of Matrix Metalloproteinases

3 of 57

2.39

2.42

0.00027

MAP-1474228

Degradation of the extracellular matrix

3 of 198

1.85

1.43

0.0052

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000088

Cardiovascular system

3 of 531

1.42

1.39

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0964

Secreted

4 of 281

1.82

2.42

3.67e-05

KW-1015

Disulfide bond

5 of 1389

1.22

1.31

0.00013

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR027465

Proteinase inhibitor I35b (TIMP), C-terminal

4 of 4

3.67

6.95

2.16e-10

IPR001820

Protease inhibitor I35 (TIMP)

4 of 4

3.67

6.95

2.16e-10

IPR030490

Tissue inhibitor of metalloproteinase, conserved site

3 of 3

3.67

4.94

1.44e-07

IPR001134

Netrin domain

4 of 33

2.75

4.9

6.79e-08

IPR008993

Tissue inhibitor of metalloproteinases-like, OB-fold

4 of 34

2.74

4.89

6.79e-08

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00206

Tissue inhibitor of metalloproteinase family.

4 of 4

3.67

7.64

2.29e-11

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