STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UBA2SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (640 aa)    
Predicted Functional Partners:
SAE1
SUMO-activating enzyme subunit 1 isoform X1.
   
0.999
UBE2I
SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.981
SUMO1
Small ubiquitin-related modifier.
   
 0.981
KCTD2
BTB/POZ domain-containing protein KCTD2.
   
 0.916
SUMO3
Small ubiquitin-related modifier 3.
   
 0.896
LOC103015513
Small ubiquitin-related modifier.
   
 0.845
LOC103016861
Small ubiquitin-related modifier 2-like.
   
 0.845
SUMO2
Small ubiquitin-related modifier.
   
 0.845
LOC103003809
Small ubiquitin-related modifier 2-like.
   
 0.762
NFATC2IP
NFATC2-interacting protein.
   
 0.749
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.