node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APAF1 | APIP | A0A383YSR8 | A0A384A173 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | 0.792 |
APAF1 | AVEN | A0A383YSR8 | A0A384A126 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cell death regulator Aven. | 0.892 |
APAF1 | TEP1 | A0A383YSR8 | A0A383ZZI8 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Telomerase protein component 1 isoform X1. | 0.461 |
APIP | APAF1 | A0A384A173 | A0A383YSR8 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.792 |
APIP | AVEN | A0A384A173 | A0A384A126 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | Cell death regulator Aven. | 0.593 |
APIP | CST6 | A0A384A173 | A0A383Z851 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | cystatin-M. | 0.439 |
APIP | CSTA | A0A384A173 | A0A383ZLC1 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | cystatin-A; Belongs to the cystatin family. | 0.439 |
APIP | TEP1 | A0A384A173 | A0A383ZZI8 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | Telomerase protein component 1 isoform X1. | 0.581 |
APOL6 | AVEN | A0A383YTE2 | A0A384A126 | Apolipoprotein L6. | Cell death regulator Aven. | 0.596 |
APOL6 | LOC103020118 | A0A383YTE2 | A0A384BEL4 | Apolipoprotein L6. | Cullin-7; Belongs to the cullin family. | 0.514 |
AVEN | APAF1 | A0A384A126 | A0A383YSR8 | Cell death regulator Aven. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.892 |
AVEN | APIP | A0A384A126 | A0A384A173 | Cell death regulator Aven. | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | 0.593 |
AVEN | APOL6 | A0A384A126 | A0A383YTE2 | Cell death regulator Aven. | Apolipoprotein L6. | 0.596 |
AVEN | CST6 | A0A384A126 | A0A383Z851 | Cell death regulator Aven. | cystatin-M. | 0.598 |
AVEN | CSTA | A0A384A126 | A0A383ZLC1 | Cell death regulator Aven. | cystatin-A; Belongs to the cystatin family. | 0.598 |
AVEN | FBXL20 | A0A384A126 | A0A383ZRQ4 | Cell death regulator Aven. | F-box/LRR-repeat protein 20. | 0.590 |
AVEN | GREM1 | A0A384A126 | A0A452CFL8 | Cell death regulator Aven. | Gremlin. | 0.522 |
AVEN | LOC103020118 | A0A384A126 | A0A384BEL4 | Cell death regulator Aven. | Cullin-7; Belongs to the cullin family. | 0.590 |
AVEN | TEP1 | A0A384A126 | A0A383ZZI8 | Cell death regulator Aven. | Telomerase protein component 1 isoform X1. | 0.692 |
AVEN | TTC7B | A0A384A126 | A0A384A0N7 | Cell death regulator Aven. | Tetratricopeptide repeat protein 7B isoform X1. | 0.593 |