STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDN04092.13-hydroxyisobutyrate dehydrogenase. (325 aa)    
Predicted Functional Partners:
SDO51553.1
2-hydroxy-3-oxopropionate reductase.
  
  
 
0.922
SDN63015.1
3-hydroxyisobutyrate dehydrogenase.
  
  
 
0.921
SDO22889.1
Short chain enoyl-CoA hydratase.
  
 
 0.918
SDO42620.1
Aldehyde dehydrogenase (acceptor).
   
 
  0.904
SDO51668.1
acetyl-CoA synthetase.
  
 
  0.898
acsA-2
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
  0.898
SDP05681.1
Methylmalonate-semialdehyde dehydrogenase [acylating].
  
 
  0.790
SDO91528.1
Malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase.
  
 
  0.789
SDP10346.1
Acyl-CoA reductase; Belongs to the aldehyde dehydrogenase family.
   
 
  0.760
SDP25883.1
Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family.
   
 
  0.760
Your Current Organism:
Streptomyces guanduensis
NCBI taxonomy Id: 310781
Other names: CGMCC 4.2022, JCM 13274, NBRC 102070, S. guanduensis, Streptomyces guanduensis Xu et al. 2006, Streptomyces sp. 701, strain 701
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