node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHK91434.1 | SHM62627.1 | SAMN05216499_10262 | SAMN05216499_112211 | 2-Methylisocitrate lyase, PEP mutase family. | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 0.830 |
SHK91434.1 | leuC | SAMN05216499_10262 | SAMN05216499_113139 | 2-Methylisocitrate lyase, PEP mutase family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.520 |
SHK91434.1 | leuD | SAMN05216499_10262 | SAMN05216499_113138 | 2-Methylisocitrate lyase, PEP mutase family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.506 |
SHM62627.1 | SHK91434.1 | SAMN05216499_112211 | SAMN05216499_10262 | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 2-Methylisocitrate lyase, PEP mutase family. | 0.830 |
SHM62627.1 | SHM71580.1 | SAMN05216499_112211 | SAMN05216499_113159 | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.837 |
SHM62627.1 | SHM71951.1 | SAMN05216499_112211 | SAMN05216499_113168 | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit. | 0.995 |
SHM62627.1 | SHN32032.1 | SAMN05216499_112211 | SAMN05216499_13716 | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | 0.824 |
SHM62627.1 | ackA | SAMN05216499_112211 | SAMN05216499_13717 | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | 0.808 |
SHM62627.1 | ilvC | SAMN05216499_112211 | SAMN05216499_113167 | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.894 |
SHM62627.1 | leuA | SAMN05216499_112211 | SAMN05216499_102353 | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.792 |
SHM62627.1 | leuB | SAMN05216499_112211 | SAMN05216499_113161 | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.801 |
SHM62627.1 | leuC | SAMN05216499_112211 | SAMN05216499_113139 | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.844 |
SHM62627.1 | leuD | SAMN05216499_112211 | SAMN05216499_113138 | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.879 |
SHM71580.1 | SHM62627.1 | SAMN05216499_113159 | SAMN05216499_112211 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 0.837 |
SHM71580.1 | SHM71951.1 | SAMN05216499_113159 | SAMN05216499_113168 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase, small subunit. | 0.984 |
SHM71580.1 | SHN32032.1 | SAMN05216499_113159 | SAMN05216499_13716 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | 0.923 |
SHM71580.1 | ackA | SAMN05216499_113159 | SAMN05216499_13717 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | 0.417 |
SHM71580.1 | ilvC | SAMN05216499_113159 | SAMN05216499_113167 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.921 |
SHM71580.1 | leuA | SAMN05216499_113159 | SAMN05216499_102353 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.915 |
SHM71580.1 | leuB | SAMN05216499_113159 | SAMN05216499_113161 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.967 |