node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHL99455.1 | SHM60719.1 | SAMN05216499_107209 | SAMN05216499_112160 | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | Malate synthase; Belongs to the malate synthase family. | 0.937 |
SHL99455.1 | SHM61710.1 | SAMN05216499_107209 | SAMN05216499_112186 | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | acetyl-CoA synthetase. | 0.937 |
SHL99455.1 | SHM71580.1 | SAMN05216499_107209 | SAMN05216499_113159 | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.929 |
SHL99455.1 | SHN32232.1 | SAMN05216499_107209 | SAMN05216499_13742 | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.929 |
SHL99455.1 | SHN34911.1 | SAMN05216499_107209 | SAMN05216499_1427 | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 2-Methylisocitrate lyase, PEP mutase family. | 0.926 |
SHL99455.1 | acsA-2 | SAMN05216499_107209 | SAMN05216499_13617 | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.936 |
SHL99455.1 | leuA | SAMN05216499_107209 | SAMN05216499_102353 | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.929 |
SHL99455.1 | sucC | SAMN05216499_107209 | SAMN05216499_101232 | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.926 |
SHL99455.1 | sucD | SAMN05216499_107209 | SAMN05216499_101233 | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.933 |
SHM60719.1 | SHL99455.1 | SAMN05216499_112160 | SAMN05216499_107209 | Malate synthase; Belongs to the malate synthase family. | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.937 |
SHM60719.1 | SHM61710.1 | SAMN05216499_112160 | SAMN05216499_112186 | Malate synthase; Belongs to the malate synthase family. | acetyl-CoA synthetase. | 0.962 |
SHM60719.1 | SHM71580.1 | SAMN05216499_112160 | SAMN05216499_113159 | Malate synthase; Belongs to the malate synthase family. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.921 |
SHM60719.1 | SHN05393.1 | SAMN05216499_112160 | SAMN05216499_11967 | Malate synthase; Belongs to the malate synthase family. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.939 |
SHM60719.1 | SHN32232.1 | SAMN05216499_112160 | SAMN05216499_13742 | Malate synthase; Belongs to the malate synthase family. | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.937 |
SHM60719.1 | SHN34911.1 | SAMN05216499_112160 | SAMN05216499_1427 | Malate synthase; Belongs to the malate synthase family. | 2-Methylisocitrate lyase, PEP mutase family. | 0.962 |
SHM60719.1 | acsA-2 | SAMN05216499_112160 | SAMN05216499_13617 | Malate synthase; Belongs to the malate synthase family. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.962 |
SHM60719.1 | leuA | SAMN05216499_112160 | SAMN05216499_102353 | Malate synthase; Belongs to the malate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.921 |
SHM60719.1 | sucC | SAMN05216499_112160 | SAMN05216499_101232 | Malate synthase; Belongs to the malate synthase family. | succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.930 |
SHM60719.1 | sucD | SAMN05216499_112160 | SAMN05216499_101233 | Malate synthase; Belongs to the malate synthase family. | succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.942 |
SHM61710.1 | SHL99455.1 | SAMN05216499_112186 | SAMN05216499_107209 | acetyl-CoA synthetase. | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.937 |