node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Avi_3711 | gpt | Avi_3711 | Avi_2602 | 5prime-nucleotidase; Belongs to the 5'-nucleotidase family. | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.908 |
Avi_3711 | guaA | Avi_3711 | Avi_0327 | 5prime-nucleotidase; Belongs to the 5'-nucleotidase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.920 |
Avi_3711 | guaA-2 | Avi_3711 | Avi_4150 | 5prime-nucleotidase; Belongs to the 5'-nucleotidase family. | GMP synthase. | 0.906 |
Avi_3711 | guaB | Avi_3711 | Avi_5770 | 5prime-nucleotidase; Belongs to the 5'-nucleotidase family. | Inosine-5`-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.911 |
Avi_3711 | hpt | Avi_3711 | Avi_4024 | 5prime-nucleotidase; Belongs to the 5'-nucleotidase family. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.904 |
Avi_3711 | purA | Avi_3711 | Avi_3544 | 5prime-nucleotidase; Belongs to the 5'-nucleotidase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.914 |
Avi_3711 | purH | Avi_3711 | Avi_4292 | 5prime-nucleotidase; Belongs to the 5'-nucleotidase family. | Bifunctional purine biosynthesis protein. | 0.910 |
Avi_3711 | rdgB | Avi_3711 | Avi_0395 | 5prime-nucleotidase; Belongs to the 5'-nucleotidase family. | Non-canonical purine NTP pyrophosphatase rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.901 |
Avi_3711 | surE | Avi_3711 | Avi_2664 | 5prime-nucleotidase; Belongs to the 5'-nucleotidase family. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.919 |
gpt | Avi_3711 | Avi_2602 | Avi_3711 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 5prime-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.908 |
gpt | guaA | Avi_2602 | Avi_0327 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.985 |
gpt | guaA-2 | Avi_2602 | Avi_4150 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | GMP synthase. | 0.923 |
gpt | guaB | Avi_2602 | Avi_5770 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | Inosine-5`-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.930 |
gpt | hpt | Avi_2602 | Avi_4024 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.927 |
gpt | purA | Avi_2602 | Avi_3544 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.469 |
gpt | purH | Avi_2602 | Avi_4292 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | Bifunctional purine biosynthesis protein. | 0.460 |
gpt | rdgB | Avi_2602 | Avi_0395 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | Non-canonical purine NTP pyrophosphatase rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.914 |
gpt | surE | Avi_2602 | Avi_2664 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.908 |
guaA | Avi_3711 | Avi_0327 | Avi_3711 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 5prime-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.920 |
guaA | gpt | Avi_0327 | Avi_2602 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.985 |