STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
BAJ50369.13-hydroxy-3-methylglutaryl-CoA reductase; Belongs to the HMG-CoA reductase family. (432 aa)    
Predicted Functional Partners:
BAJ50285.1
Mevalonate kinase.
 0.998
BAJ51320.1
Conserved hypothetical protein; 3-oxoacyl-[acyl-carrier-protein (ACP); Belongs to the thiolase-like superfamily. UPF0219 family.
  
 
 0.998
fni
Isopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
    
 0.870
BAJ51313.1
Glucose sorbosone dehydrogenase.
       0.838
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
     
 0.774
menA
Conserved hypothetical protein; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily.
   
 
 0.766
BAJ51124.1
Hypothetical protein.
       0.758
BAJ51480.1
Diphosphomevalonate decarboxylase.
 
  
 0.750
BAJ50447.1
Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family.
  
 
 0.745
BAJ50429.1
Orotidine-5'-phosphate decarboxylase.
     
 0.717
Your Current Organism:
Caldiarchaeum subterraneum
NCBI taxonomy Id: 311458
Other names: C. Caldiarchaeum subterraneum, Candidatus Caldiarchaeum subterraneum, uncultured crenarchaeote 10-H-08
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.