Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
BAJ50420.1Phosphoribosyl transferase domain protein. (190 aa)    
Predicted Functional Partners:
BAJ50593.1
Adenylosuccinate lyase.
  
 0.968
surE
5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.923
ade
Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
    
 0.921
BAJ49942.1
Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily.
   
 
  0.909
BAJ50709.1
5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase.
    
  0.900
BAJ50710.1
5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase.
    
  0.900
adkA
Adenylate kinase; Belongs to the archaeal adenylate kinase family.
     
  0.900
hisF
Imidazoleglycerol-phosphate synthase cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
 
 0.840
hisH
Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
  
 
  0.813
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.632
Your Current Organism:
Caldiarchaeum subterraneum
NCBI taxonomy Id: 311458
Other names: C. Caldiarchaeum subterraneum, Candidatus Caldiarchaeum subterraneum, uncultured crenarchaeote 10-H-08
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.