Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene co-occurrence
gene fusions
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[Homology]
Score
BAJ50804.1Helicase-associated endonuclease for fork-structured DNA; ATP-dependent RNA helicase, eif-4a family. (694 aa)    
Predicted Functional Partners:
BAJ51190.1
ERCC4 domain-containing protein.
  
 
 0.917
BAJ51472.1
Replication factor A1.
   
 0.881
pcn
Proliferating cell nuclear antigen PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
  
 
 
 0.815
rpl1
Large subunit ribosomal protein L1; Binds directly to 23S rRNA. Probably involved in E site tRNA release.
    
 0.810
BAJ50056.1
DNA topoisomerase III.
  
 
 
 0.792
BAJ51332.1
glycyl-tRNA synthetase.
       0.700
fen
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]
  
 
 0.698
BAJ50939.1
Large subunit ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
    
  0.690
BAJ50549.1
DNA repair protein RadB.
  
 
 0.673
BAJ50661.1
DNA repair protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
   
 
 0.602
Your Current Organism:
Caldiarchaeum subterraneum
NCBI taxonomy Id: 311458
Other names: C. Caldiarchaeum subterraneum, Candidatus Caldiarchaeum subterraneum, uncultured crenarchaeote 10-H-08
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