Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
BAJ50862.1Hydrogenase maturation protein HypF. (80 aa)    
Predicted Functional Partners:
BAJ50880.1
Hydrogenase expression/formation protein HypE.
  
 
 0.769
BAJ51061.1
Hydrogenase expression/formation protein HypE.
  
 
 0.769
BAJ50878.1
Hydrogenase expression/formation protein HypD.
  
  
 0.660
BAJ50869.1
Hydrogenase nickel incorporation protein HypA.
     
 0.566
BAJ50879.1
Hydrogenase expression/formation protein HypC.
  
 
 0.563
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
     
 0.550
BAJ50875.1
Nickel-dependent hydrogenase large subunit.
   
 
 0.534
BAJ50864.1
Thiamine biosynthesis protein ThiG.
       0.473
Your Current Organism:
Caldiarchaeum subterraneum
NCBI taxonomy Id: 311458
Other names: C. Caldiarchaeum subterraneum, Candidatus Caldiarchaeum subterraneum, uncultured crenarchaeote 10-H-08
Server load: low (12%) [HD]