Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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thiIThiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (398 aa)    
Predicted Functional Partners:
BAJ50864.1
Thiamine biosynthesis protein ThiG.
     
 0.905
BAJ50346.1
Conserved hypothetical protein.
 
  
 0.763
BAJ51367.1
tRNA and rRNA cytosine-C5-methylases.
 
    0.736
BAJ50996.1
Conserved hypothetical protein; N6-adenine-specific DNA methylase.
  
  
 0.732
pus10
Conserved hypothetical protein; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.
     
 0.699
BAJ50145.1
tRNA (guanine-N2-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
      
 0.693
BAJ51009.1
Conserved hypothetical protein.
       0.679
BAJ50226.1
2-methylthioadenine synthase.
  
  
 0.647
tiaS
Conserved hypothetical protein; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
      
 0.615
BAJ51041.1
ATPase.
 
  
 0.596
Your Current Organism:
Caldiarchaeum subterraneum
NCBI taxonomy Id: 311458
Other names: C. Caldiarchaeum subterraneum, Candidatus Caldiarchaeum subterraneum, uncultured crenarchaeote 10-H-08
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