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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
co-expression
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gene co-occurrence
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[Homology]
Score
BAJ51126.13-isopropylmalate dehydrogenase. (339 aa)    
Predicted Functional Partners:
BAJ50465.1
3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit.
 0.997
CSUB_C0812
3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; C-terminus of hypothetical conserved protein.
 
 
 0.994
BAJ50673.1
Acetolactate synthase I/II/III large subunit.
 0.991
BAJ51591.1
Acetolactate synthase I/II/III large subunit.
  
 0.956
BAJ49970.1
Threonine dehydratase.
  
 0.948
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
 
  
 0.907
sucC
succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.826
BAJ50895.1
Malate dehydrogenase; Belongs to the LDH/MDH superfamily.
  
 0.820
BAJ51399.1
2-isopropylmalate synthase.
 
 
 0.802
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.786
Your Current Organism:
Caldiarchaeum subterraneum
NCBI taxonomy Id: 311458
Other names: C. Caldiarchaeum subterraneum, Candidatus Caldiarchaeum subterraneum, uncultured crenarchaeote 10-H-08
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