Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (291 aa)    
Predicted Functional Partners:
lipB
Lipoyl(octanoyl) transferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
 
 0.999
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
  
 0.968
BAJ51440.1
Dihydrolipoamide dehydrogenase.
 
  
 0.887
BAJ51441.1
2-oxoisovalerate dehydrogenase E1 component, beta subunit.
  
  
 0.839
tbp
Transcription initiation factor TFIID TATA-box-binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
  
    0.701
BAJ50650.1
Conserved hypothetical protein.
  
 
 0.561
BAJ50708.1
Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase).
  
 
 0.561
BAJ51114.1
Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase).
  
 
 0.561
BAJ51443.1
NUDIX hydrolase.
       0.557
BAJ50835.1
Mercuric reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
  
  
 0.544
Your Current Organism:
Caldiarchaeum subterraneum
NCBI taxonomy Id: 311458
Other names: C. Caldiarchaeum subterraneum, Candidatus Caldiarchaeum subterraneum, uncultured crenarchaeote 10-H-08
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