Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
BAJ51498.1Citrate synthase. (380 aa)    
Predicted Functional Partners:
BAJ50637.1
Aconitate hydratase.
  
 0.997
BAJ50895.1
Malate dehydrogenase; Belongs to the LDH/MDH superfamily.
  
 0.997
BAJ50744.1
2-methylcitrate dehydratase.
 
 0.986
BAJ51114.1
Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase).
  
 0.978
fumC
Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.977
BAJ50995.1
Malate synthase.
  
 0.959
sucC
succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.953
BAJ51389.1
acetyl-CoA synthetase.
  
 0.953
BAJ50234.1
acetyl-CoA C-acyltransferase.
  
 0.951
BAJ51204.1
acetyl-CoA C-acetyltransferase; propanoyl-CoA C-acyltransferase (EC:2.3.1.176).
  
 0.951
Your Current Organism:
Caldiarchaeum subterraneum
NCBI taxonomy Id: 311458
Other names: C. Caldiarchaeum subterraneum, Candidatus Caldiarchaeum subterraneum, uncultured crenarchaeote 10-H-08
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