STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
I7MGS2_TETTSBromodomain domain protein. (883 aa)    
Predicted Functional Partners:
HHF1
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 
 0.584
Q22GJ3_TETTS
TAF7 RNA polymerase II, TATA box-binding protein.
    
 
 0.574
Q22XW0_TETTS
Animal DNA methyltransferase 1 SANT/myb-like domain protein, putative.
    
 
 0.519
Q23KL3_TETTS
Uncharacterized protein.
    
 
 0.503
HTA3
Histone H2A.Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes, preferentially in transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Essential for vegetative growth.
    
 
 0.502
W7XF42_TETTS
JmjC domain protein.
    
 
 0.477
Q23DJ9_TETTS
RuvB-like helicase; Belongs to the RuvB family.
    
 
 0.458
I7LV38_TETTS
RuvB-like helicase; Belongs to the RuvB family.
    
 
 0.457
I7LUZ3_TETTS
Histone H3; Belongs to the histone H3 family.
    
 
 0.456
HHT3
Histone H3.3; Macronuclear replacement variant which replaces conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Functions redundantly to H3.4. H3.3 deposition into chromatin is mainly tran [...]
    
 
 0.456
Your Current Organism:
Tetrahymena thermophila
NCBI taxonomy Id: 312017
Other names: T. thermophila SB210, Tetrahymena thermophila SB210
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.