STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
I7MIU3_TETTSUncharacterized protein. (2022 aa)    
Predicted Functional Partners:
Q22V14_TETTS
BRCA1 carboxy-terminus (BRCT) domain protein.
   
 
 0.833
Q23JA1_TETTS
BRCA1 carboxy-terminus (BRCT) domain protein.
   
 0.820
Q22T48_TETTS
JmjC domain protein.
    
 0.798
W7XES1_TETTS
SPRY domain protein.
    
 0.726
I7MLW8_TETTS
Type III restriction enzyme, res subunit.
   
 
 0.725
Q22G12_TETTS
Ser/thr phosphatase family protein.
    
 0.705
I7MFS9_TETTS
Small ubiquitin-related modifier.
    
 0.690
I7MFI1_TETTS
DNA repair protein RAD50, putative.
    
 0.688
HTAY
Histone H2A.Y; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
    
 0.664
HTA1
Histone H2AX; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.661
Your Current Organism:
Tetrahymena thermophila
NCBI taxonomy Id: 312017
Other names: T. thermophila SB210, Tetrahymena thermophila SB210
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.